Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

Fabry illness (FD) is an X-linked metabolic storage dysfunction arising from the deficiency of lysosomal α-galactosidase A, which ends up in the gradual accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), all through the physique. Ache within the extremities is an early symptom of FD; nevertheless, the underlying pathophysiological mechanisms stay unknown. α-Galactosidase A knockout animals exhibit

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