Aria Neurosciences

Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

Fabry illness (FD) is an X-linked metabolic storage dysfunction arising from the deficiency of lysosomal α-galactosidase A, which ends up in the gradual accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), all through the physique. Ache within the extremities is an early symptom of FD; nevertheless, the underlying pathophysiological mechanisms stay unknown. α-Galactosidase A knockout animals exhibit nociceptive behaviors, with enhanced expression ranges of a number of ion channels.

These traits are noticed in animals handled with nerve development issue (NGF). Right here, we aimed to elucidate the potential of NGF signaling as a reason behind FD-associated ache, utilizing intraplantar Gb3-treated mice displaying mechanical allodynia. Remedy with a neutralizing antibody towards a precursor of NGF (proNGF) or its receptor, p75 neurotrophin receptor (p75^NTR), resulted within the restoration from Gb3-induced ache.

Conversely, anti-NGF and anti-tropomyosin receptor kinase A antibodies did not exert analgesic results. Gb3 injection had no results on the expression ranges of proNGF and p75^NTR within the plantar pores and skin and dorsal root ganglia, suggesting that Gb3 prompts the ache pathway, presumably mediated via useful up-regulation of proNGF-p75^NTR signaling.

Moreover, by pharmacological approaches utilizing a protein kinase A (PKA) inhibitor and a cholesterol-removing agent, we discovered that p75^NTR-phosphorylating PKA and lipid rafts for phosphorylated p75^NTR translocation have been required for Gb3-induced ache. These outcomes counsel that acute publicity to Gb3 induces mechanical allodynia through activation of the proNGF-p75^NTR pathway, which includes lipid rafts and PKA. Our findings present new pathological insights into FD-associated ache, and counsel the necessity to develop therapeutic interventions concentrating on proNGF-p75^NTR signaling.

Results of NGF Addition on Llama ( Lama glama) Sperm Traits After Cooling

To offer new insights into the mechanisms via which seminal plasma proteins can defend sperm from harm induced throughout refrigeration, we consider the likelihood that β-NGF can contribute to the advance of sperm high quality after cooling. First, β-NGF was detected in refrigerated sperm and in contrast with unrefrigerated sperm by western blotting of the proteins adsorbed by sperm, displaying that native β-NGF continues to be current even 24 h after cooling solely as an energetic kind.

Then, the impact of exogenous β-NGF on sperm high quality after cooling was evaluated. A complete of 12 ejaculates from male llamas (three ejaculates per male), have been obtained by electro-ejaculation, diluted 4:1 with buffer Hepes-balanced salt answer and centrifuged at 800 × g for eight min to take away the seminal plasma. Sperm have been suspended in Tris-citrate-fructose-egg yolk diluent for a last focus of 30 ×10⁶/ml and cooled at 5°C for 24 h.

After refrigeration, the prolonged sperm have been equilibrated for five min at 37°C and divided into the next subgroups: sperm samples with out remedy (management) and sperm samples supplemented with exogenous human β-NGF (10, 100, and 500 ng/ml). At 5, 30, and 60 min of incubation sperm have been evaluated for sperm viability (utilizing eosin/nigrosin stain), sperm motility and vigor (noticed underneath gentle microscopy), and mitochondrial exercise (utilizing the JC-1 fluorescent marker).

Vigor information have been analyzed with the nonparametric Kruskal-Wallis take a look at. The remainder of the variables have been analyzed with a blended fashions method. Imply comparisons have been carried out utilizing Fisher’s LSD take a look at with a confidence stage of 95%. A principal parts evaluation was carried out to investigate the relationships between variables.

Remedy of 24 h cooled sperm with 10 or 100 ng/ml of human β-NGF elevated the share of whole motility and vigor (p < 0.05). Moreover, an incubation time of 60 min can be ample to enhance sperm high quality, since all variables are positively associated. The numerous enchancment noticed within the motility and vigor of post-refrigerated sperm means that supplementation with exogenous β-NGF could also be worthwhile for the advance of cooled llama sperm.

BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth through NGF/TrkA Signaling Pathway

Scorpion toxins signify a wide range of instruments to discover molecular mechanisms and mobile signaling pathways of many organic capabilities. These toxins are additionally promising lead compounds for growing therapies for a lot of neurological ailments. Within the present research, we purified a brand new scorpion toxin designated as BmK NSPK (Buthus martensii Karsch neurite-stimulating peptide concentrating on Okay_v channels) from the BmK venom. The first construction was decided utilizing Edman degradation.

BmK NSPK straight inhibited outward Okay⁺ present with out affecting sodium channel actions, depolarized membrane, and elevated spontaneous calcium oscillation in spinal twine neurons (SCNs) at low nanomolar concentrations. BmK NSPK produced a nonmonotonic enhance on the neurite extension that peaked at ~10 nM. Mechanistic research demonstrated that BmK NSPK elevated the discharge of nerve development issue (NGF).

The tyrosine kinases A (TrkA) receptor inhibitor, GW 441756, eradicated the BmK NSPK-induced neurite outgrowth. BmK NSPK additionally elevated phosphorylation ranges of protein kinase B (Akt) that’s the downstream regulator of TrkA receptors.

HGF antibody
70R-6637	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal HGF antibody

HGF Antibody
ABD6326	Lifescience Market	100 ug	EUR 525.6

HGF antibody
10R-H138A	Fitzgerald	500 ug	EUR 1504
Description: Mouse monoclonal HGF antibody

HGF Antibody
1-CSB-PA254609	Cusabio	Ask for price Ask for price	50ul 100ul
Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

HGF Antibody
CSB-PA010327KA01HU-	Cusabio	each	EUR 402
Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:200-1:500, IHC:1:50-1:100

HGF Antibody
CSB-PA010327KA01HU-100ul	Cusabio	100ul	EUR 466.8
Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:200-1:500, IHC:1:50-1:100

HGF Antibody
1-CSB-PA783451	Cusabio	Ask for price Ask for price	50ug 100ug
Description: A polyclonal antibody against HGF. Recognizes HGF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

HGF Antibody
1-CSB-PA221214	Cusabio	Ask for price Ask for price	50ul 100ul
Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

HGF Antibody
DF6326	Affbiotech	200ul	EUR 420

HGF Antibody
DF6326-100ul	Affinity Biosciences	100ul	EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

HGF Antibody
DF6326-200ul	Affinity Biosciences	200ul	EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

HGF Antibody
C30161-100ul	Assay Biotech	100μl	EUR 217
Description: HGF Rabbit Polyclonal Antibody

HGF Antibody
C30161-50ul	Assay Biotech	50μl	EUR 143.5
Description: HGF Rabbit Polyclonal Antibody

Hgf Antibody
CSB-PA084844ZA01RA-02mg	Cusabio	0.2mg	Ask for price
Description: Recombinant Rattus norvegicus Hgf protein

Hgf Antibody
CSB-PA084844ZA01RA-10mg	Cusabio	10mg	Ask for price
Description: Recombinant Rattus norvegicus Hgf protein

HGF Antibody
GWB-A5AD09	GenWay Biotech	0.5 ml	Ask for price

HGF Antibody
GWB-C4428D	GenWay Biotech	0.1 mg	Ask for price

HGF Antibody
GWB-65772C	GenWay Biotech	0.025 mg	Ask for price

HGF Antibody
GWB-2DD843	GenWay Biotech	0.1 mg	Ask for price

HGF Antibody
GWB-8540C0	GenWay Biotech	0.125 ml	Ask for price

HGF Antibody
GWB-MP787D	GenWay Biotech	50ug	Ask for price

HGF Antibody
GWB-MP788E	GenWay Biotech	50ug	Ask for price

HGF Antibody
GWB-MP789F	GenWay Biotech	50ug	Ask for price

HGF Antibody
E314073	EnoGene	200ul	EUR 275
Description: Available in various conjugation types.

HGF Antibody
E45M02413G-1	EnoGene	100 ul	EUR 395

HGF Antibody
E45M02413G-4	EnoGene	50 ul	EUR 295

HGF Antibody
E19-6326	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

HGF Antibody
E91193	EnoGene	100ul	EUR 255
Description: Available in various conjugation types.

HGF Antibody
MBS5312650-01mg	MyBiosource	0.1mg	EUR 975

HGF Antibody
MBS5312650-5x01mg	MyBiosource	5x0.1mg	EUR 4245

HGF antibody
MBS534438-01mg	MyBiosource	0.1mg	EUR 1470

HGF antibody
MBS534438-5x01mg	MyBiosource	5x0.1mg	EUR 6455

HGF Antibody
MBS2526824-002mL	MyBiosource	0.02mL	EUR 140

HGF Antibody
MBS2526824-006mL	MyBiosource	0.06mL	EUR 180

HGF Antibody
MBS2526824-012mL	MyBiosource	0.12mL	EUR 260

HGF Antibody
MBS2526824-02mL	MyBiosource	0.2mL	EUR 405

HGF antibody
MBS530424-05mg	MyBiosource	0.5mg	EUR 2265

HGF antibody
MBS530424-5x05mg	MyBiosource	5x0.5mg	EUR 10035

HGF Antibody
MBS7122747-005mg	MyBiosource	0.05mg	EUR 150

HGF Antibody
MBS7122747-01mg	MyBiosource	0.1mg	EUR 190

HGF Antibody
MBS7122747-5x01mg	MyBiosource	5x0.1mg	EUR 845

HGF Antibody
MBS7123778-005mL	MyBiosource	0.05mL	EUR 190

HGF Antibody
MBS7123778-01mL	MyBiosource	0.1mL	EUR 270

HGF Antibody
MBS7123778-5x01mL	MyBiosource	5x0.1mL	EUR 1205

HGF Antibody
MBS7123779-005mL	MyBiosource	0.05mL	EUR 190

HGF Antibody
MBS7123779-01mL	MyBiosource	0.1mL	EUR 270

HGF Antibody
MBS7123779-5x01mL	MyBiosource	5x0.1mL	EUR 1205

HGF Antibody
MBS9606984-01mL	MyBiosource	0.1mL	EUR 260

HGF Antibody
MBS9606984-02mL	MyBiosource	0.2mL	EUR 305

HGF Antibody
MBS9606984-5x02mL	MyBiosource	5x0.2mL	EUR 1220

HGF Antibody
MBS9200300-008mL	MyBiosource	0.08mL	EUR 210

HGF Antibody
MBS9200300-04mL	MyBiosource	0.4mL	EUR 430

HGF Antibody
MBS9200300-5x04mL	MyBiosource	5x0.4mL	EUR 1910

HGF Antibody
MBS8501441-01mL	MyBiosource	0.1mL	EUR 325

HGF Antibody
MBS8501441-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

HGF Antibody
MBS8501441-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

HGF Antibody
MBS8501441-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

HGF Antibody
MBS8501441-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

HGF Antibody
MBS8516210-01mg	MyBiosource	0.1mg	EUR 305

HGF Antibody
MBS8516210-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

HGF Antibody
MBS8516210-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

HGF Antibody
MBS8516210-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

HGF Antibody
MBS8516210-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

HGF Antibody
MBS9507398-005mL	MyBiosource	0.05mL	EUR 285

HGF Antibody
MBS9507398-01mL	MyBiosource	0.1mL	EUR 385

HGF Antibody
MBS9507398-5x01mL	MyBiosource	5x0.1mL	EUR 1590

HGF Antibody
MBS9408578-005mL	MyBiosource	0.05mL	EUR 300

HGF Antibody
MBS9408578-01mL	MyBiosource	0.1mL	EUR 390

HGF Antibody
MBS9408578-5x01mL	MyBiosource	5x0.1mL	EUR 1610

Human HGF Antibody
32740-05111	AssayPro	150 ug	EUR 215

HGF antibody (biotin)
60R-HG003BT	Fitzgerald	100 ug	EUR 861
Description: Goat polyclonal HGF antibody (biotin) conjugated

HGF antibody (biotin)
MBS534011-01mg	MyBiosource	0.1mg	EUR 1315

HGF antibody (biotin)
MBS534011-5x01mg	MyBiosource	5x0.1mg	EUR 5765

HGF Antibody (C-term)
E45R31512G-1	EnoGene	100 ul	EUR 395

HGF Antibody (C-term)
E45R31512G-4	EnoGene	50 ul	EUR 295

HGF Antibody (C-term)
MBS9206386-008mL	MyBiosource	0.08mL	EUR 210

HGF Antibody (C-term)
MBS9206386-04mL	MyBiosource	0.4mL	EUR 430

HGF Antibody (C-term)
MBS9206386-5x04mL	MyBiosource	5x0.4mL	EUR 1910

Anti-Human HGF Antibody
101-M449	ReliaTech	100 µg	EUR 399
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF (or scatter factor) signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody
101-M769	ReliaTech	100 µg	EUR 399
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF (or scatter factor) signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody
102-PA62AG	ReliaTech	50 µg	EUR 157.5
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody
102-PA62S	ReliaTech	100 µg	EUR 126
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody
MBS1569865-01mg	MyBiosource	0.1mg	EUR 375

Anti-Human HGF Antibody
MBS1569865-5x01mg	MyBiosource	5x0.1mg	EUR 1390

HGF antibody - middle region
MBS3207318-01mL	MyBiosource	0.1mL	EUR 455

HGF antibody - middle region
MBS3207318-5x01mL	MyBiosource	5x0.1mL	EUR 1995

HGF Antibody HRP Conjugated
MBS9460205-01mL	MyBiosource	0.1mL	EUR 595

HGF Antibody HRP Conjugated
MBS9460205-5x01mL	MyBiosource	5x0.1mL	EUR 2525

OACD04909-1ML - HGF Antibody
OACD04909-1ML	Aviva Systems Biology	1ml	EUR 639

HGF Antibody FITC Conjugated
MBS9460206-01mL	MyBiosource	0.1mL	EUR 595

HGF Antibody FITC Conjugated
MBS9460206-5x01mL	MyBiosource	5x0.1mL	EUR 2525

HGF receptor Antibody
GWB-3AD21B	GenWay Biotech	0.025 mg	Ask for price

HGF receptor Antibody
GWB-3D99F3	GenWay Biotech	0.025 mg	Ask for price

OALA03205-50UG - HGF Antibody
OALA03205-50UG	Aviva Systems Biology	50ug	EUR 539

OAAB07048-400UL - HGF Antibody
OAAB07048-400UL	Aviva Systems Biology	400ul	EUR 409

OAAJ06800-100UL - HGF Antibody
OAAJ06800-100UL	Aviva Systems Biology	100uL	EUR 319

OACD04909-100UL - HGF Antibody
OACD04909-100UL	Aviva Systems Biology	100ul	EUR 189

HGF activator Antibody
20-abx141127	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

HGF Polyclonal Antibody
ABP57387-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF Polyclonal Antibody
ABP57387-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF Polyclonal Antibody
ABP57387-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF polyclonal antibody
BS67261	Bioworld Biotech	50ul	EUR 275
Description: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

HGF Polyclonal Antibody
E-AB-60245-120uL	Elabscience Biotech	120uL	EUR 320
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-60245-200uL	Elabscience Biotech	200uL	EUR 530
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-60245-60uL	Elabscience Biotech	60uL	EUR 200
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-60245-each	Elabscience Biotech	each	Ask for price
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-10362-120uL	Elabscience Biotech	120uL	EUR 240
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-10362-200uL	Elabscience Biotech	200uL	EUR 399
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-10362-20uL	Elabscience Biotech	20uL	EUR 73
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-10362-60uL	Elabscience Biotech	60uL	EUR 143
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-14122-120uL	Elabscience Biotech	120uL	EUR 240
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-14122-200uL	Elabscience Biotech	200uL	EUR 399
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-14122-20uL	Elabscience Biotech	20uL	EUR 73
Description: Unconjugated

HGF Polyclonal Antibody
E-AB-14122-60uL	Elabscience Biotech	60uL	EUR 143
Description: Unconjugated

HGF polyclonal antibody
BS6234	Bioworld Biotech	50 ul	EUR 358
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

HGF Polyclonal Antibody
BT-AP03956-100ul	Jiaxing Korain Biotech Ltd (BT Labs)	100ul	Ask for price
Description: HGF (hepatocyte growth factor) encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in HGF are associated with nonsyndromic hearing loss.

HGF Polyclonal Antibody
BT-AP03956-20ul	Jiaxing Korain Biotech Ltd (BT Labs)	20ul	Ask for price
Description: HGF (hepatocyte growth factor) encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in HGF are associated with nonsyndromic hearing loss.

HGF Polyclonal Antibody
BT-AP03956-50ul	Jiaxing Korain Biotech Ltd (BT Labs)	50ul	Ask for price
Description: HGF (hepatocyte growth factor) encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in HGF are associated with nonsyndromic hearing loss.

HGF Conjugated Antibody
C32218	SAB	100ul	EUR 476.4

HGF Polyclonal Antibody
MBS127456-002mL	MyBiosource	0.02mL	EUR 200

HGF Polyclonal Antibody
MBS127456-005mL	MyBiosource	0.05mL	EUR 255

HGF Polyclonal Antibody
MBS127456-01mL	MyBiosource	0.1mL	EUR 345

HGF Polyclonal Antibody
MBS127456-02mL	MyBiosource	0.2mL	EUR 545

HGF Polyclonal Antibody
MBS127456-5x02mL	MyBiosource	5x0.2mL	EUR 2265

HGF Polyclonal Antibody
JOT-AP03956-100ul	Jotbody	100ul	EUR 220
Description: Human

HGF Polyclonal Antibody
JOT-AP03956-50ul	Jotbody	50ul	EUR 144
Description: Human

HGF monoclonal antibody
MB66884	Bioworld Biotech	50ul	EUR 275
Description: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

HGF Polyclonal Antibody
E20-75699	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

HGF Polyclonal Antibody
E44H07141	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HGF Polyclonal Antibody
MBS2554144-006mL	MyBiosource	0.06mL	EUR 190

HGF Polyclonal Antibody
MBS2554144-012mL	MyBiosource	0.12mL	EUR 265

HGF Polyclonal Antibody
MBS2554144-02mL	MyBiosource	0.2mL	EUR 415

HGF Polyclonal Antibody
MBS2554144-5x02mL	MyBiosource	5x0.2mL	EUR 1835

HGF Polyclonal Antibody
MBS2518820-002mL	MyBiosource	0.02mL	EUR 135

HGF Polyclonal Antibody
MBS2518820-006mL	MyBiosource	0.06mL	EUR 190

HGF Polyclonal Antibody
MBS2518820-012mL	MyBiosource	0.12mL	EUR 265

HGF Polyclonal Antibody
MBS2518820-02mL	MyBiosource	0.2mL	EUR 415

HGF Polyclonal Antibody
MBS2518820-5x02mL	MyBiosource	5x0.2mL	EUR 1835

HGF Polyclonal Antibody
MBS2523474-002mL	MyBiosource	0.02mL	EUR 135

HGF Polyclonal Antibody
MBS2523474-006mL	MyBiosource	0.06mL	EUR 190

HGF Polyclonal Antibody
MBS2523474-012mL	MyBiosource	0.12mL	EUR 265

HGF Polyclonal Antibody
MBS2523474-02mL	MyBiosource	0.2mL	EUR 415

HGF Polyclonal Antibody
MBS2523474-5x02mL	MyBiosource	5x0.2mL	EUR 1835

HGF Polyclonal Antibody
MBS9246315-01mL	MyBiosource	0.1mL	EUR 415

HGF Polyclonal Antibody
MBS9246315-5x01mL	MyBiosource	5x0.1mL	EUR 1841

HGF Polyclonal Antibody
MBS8526680-01mg	MyBiosource	0.1mg	EUR 305

HGF Polyclonal Antibody
MBS8526680-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

HGF Polyclonal Antibody
MBS8526680-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

HGF Polyclonal Antibody
MBS8526680-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

HGF Polyclonal Antibody
MBS8526680-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

HGF Conjugated Antibody
MBS9443364-01mLAF350	MyBiosource	0.1mL(AF350)	EUR 480

HGF Conjugated Antibody
MBS9443364-01mLAF405	MyBiosource	0.1mL(AF405)	EUR 480

HGF Conjugated Antibody
MBS9443364-01mLAF488	MyBiosource	0.1mL(AF488)	EUR 480

HGF Conjugated Antibody
MBS9443364-01mLAF555	MyBiosource	0.1mL(AF555)	EUR 480

HGF Conjugated Antibody
MBS9443364-01mLBiotin	MyBiosource	0.1mL(Biotin)	EUR 480

HGF Polyclonal Antibody
RD75200A-120uL	Reddot Biotech	120μL	EUR 360
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD75200A-200uL	Reddot Biotech	200μL	EUR 630
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD75200A-20uL	Reddot Biotech	20μL	EUR 109.5
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD75200A-60uL	Reddot Biotech	60μL	EUR 214.5
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD80732A-120uL	Reddot Biotech	120μL	EUR 360
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

HGF Polyclonal Antibody
RD80732A-200uL	Reddot Biotech	200μL	EUR 630
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

HGF Polyclonal Antibody
RD80732A-60uL	Reddot Biotech	60μL	EUR 204
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

HGF Polyclonal Antibody
RD77446A-120uL	Reddot Biotech	120μL	EUR 360
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD77446A-200uL	Reddot Biotech	200μL	EUR 630
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD77446A-20uL	Reddot Biotech	20μL	EUR 109.5
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
RD77446A-60uL	Reddot Biotech	60μL	EUR 214.5
Description: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.

HGF Polyclonal Antibody
UB-GEN-15492	UpingBio	100 ul	EUR 200

Anti-Human HGF Antibody (SFN68)
MBS1569198-01mg	MyBiosource	0.1mg	EUR 375

Anti-Human HGF Antibody (SFN68)
MBS1569198-5x01mg	MyBiosource	5x0.1mg	EUR 1390

HGF antibody - N-terminal region
MBS3207316-01mL	MyBiosource	0.1mL	EUR 455

HGF antibody - N-terminal region
MBS3207316-5x01mL	MyBiosource	5x0.1mL	EUR 1995

HGF antibody - N-terminal region
MBS3207317-01mL	MyBiosource	0.1mL	EUR 455

HGF antibody - N-terminal region
MBS3207317-5x01mL	MyBiosource	5x0.1mL	EUR 1995

Human HGF Antibody (Biotin Conjugate)
32740-05121	AssayPro	150 ug	EUR 315

Monoclonal HGF Antibody, Clone: 489CT6.12.6
AMM02413G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human HGF. The antibodies are raised in Mouse and are from clone 489CT6.12.6. This antibody is applicable in WB, E

Hepatocyte Growth Factor (HGF) Antibody
abx001106-100l	Abbexa	100 µl	EUR 400

Hepatocyte Growth Factor (HGF) Antibody
20-abx001106	Abbexa	Ask for price Ask for price Ask for price Ask for price	20 ul 50 ul 100 ul 200 ul

Hepatocyte Growth Factor (HGF) Antibody
abx001106-20l	Abbexa	20 µl	EUR 175

Hepatocyte Growth Factor (HGF) Antibody
abx001106-50l	Abbexa	50 µl	EUR 275

Hepatocyte Growth Factor (HGF) Antibody
abx029391-400l	Abbexa	400 µl	EUR 518.75

Hepatocyte Growth Factor (HGF) Antibody
abx029391-400ul	Abbexa	400 ul	EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody
abx029391-80l	Abbexa	80 µl	EUR 250

Hepatocyte Growth Factor (HGF) Antibody
abx025436-100ul	Abbexa	100 ul	EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody
abx025437-400l	Abbexa	400 µl	EUR 518.75

Hepatocyte Growth Factor (HGF) Antibody
abx025437-400ul	Abbexa	400 ul	EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody
abx025437-80l	Abbexa	80 µl	EUR 281.25

Hepatocyte Growth Factor (HGF) Antibody
abx102372-100l	Abbexa	100 µl	EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody
20-abx102372	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Hepatocyte Growth Factor (HGF) Antibody
abx102372-1ml	Abbexa	1 ml	EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody
abx102372-200l	Abbexa	200 µl	EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody
abx102373-100l	Abbexa	100 µl	EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody
20-abx102373	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Hepatocyte Growth Factor (HGF) Antibody
abx102373-1ml	Abbexa	1 ml	EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody
abx102373-200l	Abbexa	200 µl	EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody
abx102374-100l	Abbexa	100 µl	EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody
20-abx102374	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	10 ug 50 ug 100 ug 200 ug 1 mg

Hepatocyte Growth Factor (HGF) Antibody
abx102374-1ml	Abbexa	1 ml	EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody
abx102374-200l	Abbexa	200 µl	EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody
abx102375-100l	Abbexa	100 µl	EUR 237.5

Hepatocyte Growth Factor (HGF) Antibody
20-abx102375	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Hepatocyte Growth Factor (HGF) Antibody
abx102375-1ml	Abbexa	1 ml	EUR 625

These information show that BmK NSPK is a brand new voltage-gated potassium (Okay_v) channel inhibitor that augments neurite extension through NGF/TrkA signaling pathway. Okay_v channels could signify molecular targets to modulate SCN improvement and regeneration and to develop the therapies for spinal twine damage.