Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

Fabry illness (FD) is an X-linked metabolic storage dysfunction arising from the deficiency of lysosomal α-galactosidase A, which ends up in the gradual accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), all through the physique. Ache within the extremities is an early symptom of FD; nevertheless, the underlying pathophysiological mechanisms stay unknown. α-Galactosidase A knockout animals exhibit nociceptive behaviors, with enhanced expression ranges of a number of ion channels.

These traits are noticed in animals handled with nerve development issue (NGF). Right here, we aimed to elucidate the potential of NGF signaling as a reason behind FD-associated ache, utilizing intraplantar Gb3-treated mice displaying mechanical allodynia. Remedy with a neutralizing antibody towards a precursor of NGF (proNGF) or its receptor, p75 neurotrophin receptor (p75NTR), resulted within the restoration from Gb3-induced ache.

Conversely, anti-NGF and anti-tropomyosin receptor kinase A antibodies did not exert analgesic results. Gb3 injection had no results on the expression ranges of proNGF and p75NTR within the plantar pores and skin and dorsal root ganglia, suggesting that Gb3 prompts the ache pathway, presumably mediated via useful up-regulation of proNGF-p75NTR signaling.

Moreover, by pharmacological approaches utilizing a protein kinase A (PKA) inhibitor and a cholesterol-removing agent, we discovered that p75NTR-phosphorylating PKA and lipid rafts for phosphorylated p75NTR translocation have been required for Gb3-induced ache. These outcomes counsel that acute publicity to Gb3 induces mechanical allodynia through activation of the proNGF-p75NTR pathway, which includes lipid rafts and PKA. Our findings present new pathological insights into FD-associated ache, and counsel the necessity to develop therapeutic interventions concentrating on proNGF-p75NTR signaling.

Results of NGF Addition on Llama ( Lama glama) Sperm Traits After Cooling

To offer new insights into the mechanisms via which seminal plasma proteins can defend sperm from harm induced throughout refrigeration, we consider the likelihood that β-NGF can contribute to the advance of sperm high quality after cooling. First, β-NGF was detected in refrigerated sperm and in contrast with unrefrigerated sperm by western blotting of the proteins adsorbed by sperm, displaying that native β-NGF continues to be current even 24 h after cooling solely as an energetic kind.

Then, the impact of exogenous β-NGF on sperm high quality after cooling was evaluated. A complete of 12 ejaculates from male llamas (three ejaculates per male), have been obtained by electro-ejaculation, diluted 4:1 with buffer Hepes-balanced salt answer and centrifuged at 800 × g for eight min to take away the seminal plasma. Sperm have been suspended in Tris-citrate-fructose-egg yolk diluent for a last focus of 30 ×106/ml and cooled at 5°C for 24 h.

After refrigeration, the prolonged sperm have been equilibrated for five min at 37°C and divided into the next subgroups: sperm samples with out remedy (management) and sperm samples supplemented with exogenous human β-NGF (10, 100, and 500 ng/ml). At 5, 30, and 60 min of incubation sperm have been evaluated for sperm viability (utilizing eosin/nigrosin stain), sperm motility and vigor (noticed underneath gentle microscopy), and mitochondrial exercise (utilizing the JC-1 fluorescent marker).

Vigor information have been analyzed with the nonparametric Kruskal-Wallis take a look at. The remainder of the variables have been analyzed with a blended fashions method. Imply comparisons have been carried out utilizing Fisher’s LSD take a look at with a confidence stage of 95%. A principal parts evaluation was carried out to investigate the relationships between variables.

Remedy of 24 h cooled sperm with 10 or 100 ng/ml of human β-NGF elevated the share of whole motility and vigor (p < 0.05). Moreover, an incubation time of 60 min can be ample to enhance sperm high quality, since all variables are positively associated. The numerous enchancment noticed within the motility and vigor of post-refrigerated sperm means that supplementation with exogenous β-NGF could also be worthwhile for the advance of cooled llama sperm.

Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75 NTR but not mature NGF-TrkA

BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth through NGF/TrkA Signaling Pathway

Scorpion toxins signify a wide range of instruments to discover molecular mechanisms and mobile signaling pathways of many organic capabilities. These toxins are additionally promising lead compounds for growing therapies for a lot of neurological ailments. Within the present research, we purified a brand new scorpion toxin designated as BmK NSPK (Buthus martensii Karsch neurite-stimulating peptide concentrating on Okayv channels) from the BmK venom. The first construction was decided utilizing Edman degradation.

BmK NSPK straight inhibited outward Okay+ present with out affecting sodium channel actions, depolarized membrane, and elevated spontaneous calcium oscillation in spinal twine neurons (SCNs) at low nanomolar concentrations. BmK NSPK produced a nonmonotonic enhance on the neurite extension that peaked at ~10 nM. Mechanistic research demonstrated that BmK NSPK elevated the discharge of nerve development issue (NGF).

The tyrosine kinases A (TrkA) receptor inhibitor, GW 441756, eradicated the BmK NSPK-induced neurite outgrowth. BmK NSPK additionally elevated phosphorylation ranges of protein kinase B (Akt) that’s the downstream regulator of TrkA receptors.

HGF Antibody

E314073 200ul
EUR 275
Description: Available in various conjugation types.

HGF Antibody

E91193 100ul
EUR 255
Description: Available in various conjugation types.

HGF Antibody

F40371-0.4ML 0.4 ml
EUR 322.15
Description: Hepatocyte Growth Factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 64-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq].

HGF Antibody

GWB-2DD843 0.1 mg Ask for price

HGF Antibody

DF6326 200ul
EUR 420

HGF Antibody

DF6326-100ul 100ul
EUR 280

HGF Antibody

DF6326-200ul 200ul
EUR 350

HGF antibody

70R-HG004 100 ug
EUR 914
Description: Affinity purified Goat polyclonal HGF antibody

HGF antibody

70R-13854 100 ug
EUR 519
Description: Affinity purified Goat polyclonal HGF antibody

HGF antibody

70R-11547 100 ug
EUR 638.4
Description: Rabbit polyclonal HGF antibody

HGF antibody

70R-8599 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal HGF antibody

HGF antibody

70R-5700 50 ug
EUR 467
Description: Rabbit polyclonal HGF antibody

HGF antibody

70R-6637 50 ug
EUR 467
Description: Rabbit polyclonal HGF antibody

HGF Antibody

ABD6326 100 ug
EUR 525.6

HGF Antibody

1-CSB-PA221214
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Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

HGF Antibody

1-CSB-PA254609
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Description: A polyclonal antibody against HGF. Recognizes HGF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

HGF Antibody

1-CSB-PA783451
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Description: A polyclonal antibody against HGF. Recognizes HGF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

HGF Antibody

GWB-A5AD09 0.5 ml Ask for price

HGF Antibody

GWB-65772C 0.025 mg Ask for price

HGF Antibody

GWB-8540C0 0.125 ml Ask for price

HGF Antibody

GWB-MP787D 50ug Ask for price

HGF Antibody

GWB-MP788E 50ug Ask for price

HGF Antibody

GWB-MP789F 50ug Ask for price

HGF Antibody

GWB-C4428D 0.1 mg Ask for price

HGF Antibody

R30164 100 ug
EUR 356.15
Description: Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. This gene is mapped to 7q21.11. It is secreted by mesenchymal cells and targets and acts primarily uponepithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration and in wound healing. HGF can regulate cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF also serves as a paracrine mediator to control placental development and growth. HGF was identified as one of the liver sinusoidal endothelial cell-derived paracrine mediators promoting hepatocyte growth.

Human HGF Antibody

32740-05111 150 ug
EUR 215

HGF antibody (biotin)

60R-HG003BT 100 ug
EUR 861
Description: Goat polyclonal HGF antibody (biotin) conjugated

Anti-Human HGF Antibody

102-PA62AG 50 µg
EUR 157.5
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody

102-PA62S 100 µg
EUR 126
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody

101-M449 100 µg
EUR 399
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF (or scatter factor) signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

Anti-Human HGF Antibody

101-M769 100 µg
EUR 399
Description: HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF (or scatter factor) signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.

OACD04909-1ML - HGF Antibody

OACD04909-1ML 1ml
EUR 639

OALA03205-50UG - HGF Antibody

OALA03205-50UG 50ug
EUR 539

HGF receptor Antibody

GWB-3AD21B 0.025 mg Ask for price

HGF receptor Antibody

GWB-3D99F3 0.025 mg Ask for price

OAAJ06800-100UL - HGF Antibody

OAAJ06800-100UL 100uL
EUR 319

OAAB07048-400UL - HGF Antibody

OAAB07048-400UL 400ul
EUR 409

OACD04909-100UL - HGF Antibody

OACD04909-100UL 100ul
EUR 189

HGF activator Antibody

20-abx141127
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HGF Polyclonal Antibody

E20-75699 100ug
EUR 225
Description: Available in various conjugation types.

HGF Conjugated Antibody

C32218 100ul
EUR 476.4

HGF Polyclonal Antibody

ABP57387-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF Polyclonal Antibody

ABP57387-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF Polyclonal Antibody

ABP57387-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of HGF from Human. This HGF antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human HGF

HGF Polyclonal Antibody

E44H07141 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HGF Polyclonal Antibody

E-AB-60245-120uL 120uL
EUR 320
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-60245-200uL 200uL
EUR 530
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-60245-60uL 60uL
EUR 200
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-60245-each each Ask for price
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-10362-120uL 120uL
EUR 240
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-10362-200uL 200uL
EUR 399
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-10362-20uL 20uL
EUR 73
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-10362-60uL 60uL
EUR 143
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-14122-120uL 120uL
EUR 240
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-14122-200uL 200uL
EUR 399
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-14122-20uL 20uL
EUR 73
Description: Unconjugated

HGF Polyclonal Antibody

E-AB-14122-60uL 60uL
EUR 143
Description: Unconjugated

Human HGF Antibody (Biotin Conjugate)

32740-05121 150 ug
EUR 315

Monoclonal HGF Antibody, Clone: 489CT6.12.6

AMM02413G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human HGF. The antibodies are raised in Mouse and are from clone 489CT6.12.6. This antibody is applicable in WB, E

Hepatocyte Growth Factor (HGF) Antibody

20-abx323389
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Hepatocyte Growth Factor (HGF) Antibody

20-abx172782
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  • 1 mg
  • 200 ug

Hepatocyte Growth Factor (HGF) Antibody

20-abx172783
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  • 1 mg
  • 200 ug

Hepatocyte Growth Factor (HGF) Antibody

20-abx172784
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  • 1 mg
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Hepatocyte Growth Factor (HGF) Antibody

20-abx172785
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  • 1 mg
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Hepatocyte Growth Factor (HGF) Antibody

20-abx176817
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  • 1 mg
  • 200 ug

Hepatocyte Growth Factor (HGF) Antibody

20-abx176819
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  • 1 mg
  • 200 ug

Hepatocyte Growth Factor (HGF) Antibody

20-abx241534
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  • 100 ul
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Hepatocyte Growth Factor (HGF) Antibody

20-abx241535
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  • 100 ul
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Hepatocyte Growth Factor (HGF) Antibody

20-abx141201
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Hepatocyte Growth Factor (HGF) Antibody

20-abx104891
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  • 100 ug
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Hepatocyte Growth Factor (HGF) Antibody

abx117058-100ug 100 ug
EUR 560.4

Hepatocyte Growth Factor (HGF) Antibody

20-abx102372
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Hepatocyte Growth Factor (HGF) Antibody

20-abx102373
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Hepatocyte Growth Factor (HGF) Antibody

20-abx102374
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Hepatocyte Growth Factor (HGF) Antibody

20-abx102375
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Hepatocyte Growth Factor (HGF) Antibody

20-abx102376
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Hepatocyte Growth Factor (HGF) Antibody

20-abx102377
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Hepatocyte Growth Factor (HGF) Antibody

20-abx001106
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Hepatocyte Growth Factor (HGF) Antibody

abx025436-100ul 100 ul
EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody

abx025437-400ul 400 ul
EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody

abx025437-80l 80 µl
EUR 343.2

Hepatocyte Growth Factor (HGF) Antibody

abx029391-400ul 400 ul
EUR 627.6

Hepatocyte Growth Factor (HGF) Antibody

abx029391-80l 80 µl
EUR 343.2

Hepatocyte Growth Factor (HGF) Antibody

abx001106-100l 100 µl
EUR 400

Hepatocyte Growth Factor (HGF) Antibody

abx001106-20l 20 µl
EUR 175

Hepatocyte Growth Factor (HGF) Antibody

abx001106-50l 50 µl
EUR 275

Hepatocyte Growth Factor (HGF) Antibody

abx104891-100g 100 µg
EUR 775

Hepatocyte Growth Factor (HGF) Antibody

abx104891-20g 20 µg
EUR 275

Hepatocyte Growth Factor (HGF) Antibody

abx104891-50g 50 µg
EUR 350

Hepatocyte Growth Factor (HGF) Antibody

abx117058-100g 100 µg
EUR 450

Hepatocyte Growth Factor (HGF) Antibody

abx025437-400l 400 µl
EUR 518.75

Hepatocyte Growth Factor (HGF) Antibody

abx102372-100l 100 µl
EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody

abx102372-1ml 1 ml
EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody

abx102372-200l 200 µl
EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody

abx102373-100l 100 µl
EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody

abx102373-1ml 1 ml
EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody

abx102373-200l 200 µl
EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody

abx102374-100l 100 µl
EUR 212.5

Hepatocyte Growth Factor (HGF) Antibody

abx102374-1ml 1 ml
EUR 487.5

Hepatocyte Growth Factor (HGF) Antibody

abx102374-200l 200 µl
EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody

abx102375-100l 100 µl
EUR 237.5

Hepatocyte Growth Factor (HGF) Antibody

abx102375-1ml 1 ml
EUR 625

Hepatocyte Growth Factor (HGF) Antibody

abx102375-200l 200 µl
EUR 300

Hepatocyte Growth Factor (HGF) Antibody

abx102376-100l 100 µl
EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody

abx102376-1ml 1 ml
EUR 687.5

Hepatocyte Growth Factor (HGF) Antibody

abx102376-200l 200 µl
EUR 325

Hepatocyte Growth Factor (HGF) Antibody

abx102377-100l 100 µl
EUR 262.5

Hepatocyte Growth Factor (HGF) Antibody

abx102377-1ml 1 ml
EUR 725

Hepatocyte Growth Factor (HGF) Antibody

abx102377-200l 200 µl
EUR 337.5

Hepatocyte Growth Factor (HGF) Antibody

abx218539-100tests 100 tests Ask for price

Hepatocyte Growth Factor (HGF) Antibody

abx218539-200tests 200 tests Ask for price

Hepatocyte Growth Factor (HGF) Antibody

abx218539-20tests 20 tests
EUR 350

Hepatocyte Growth Factor (HGF) Antibody

abx241534-100g 100 µg
EUR 350

Hepatocyte Growth Factor (HGF) Antibody

abx241534-10g 10 µg
EUR 250

Hepatocyte Growth Factor (HGF) Antibody

abx241534-200g 200 µg Ask for price

Hepatocyte Growth Factor (HGF) Antibody

abx241535-100g 100 µg
EUR 350

Hepatocyte Growth Factor (HGF) Antibody

abx241535-10g 10 µg
EUR 250

Hepatocyte Growth Factor (HGF) Antibody

abx241535-200g 200 µg Ask for price

Hepatocyte Growth Factor (HGF) Antibody

abx029391-400l 400 µl
EUR 518.75

Hepatocyte Growth Factor (HGF) Antibody

abx172782-1ml 1 ml
EUR 775

Hepatocyte Growth Factor (HGF) Antibody

abx172783-1ml 1 ml
EUR 775

Hepatocyte Growth Factor (HGF) Antibody

abx172784-1ml 1 ml
EUR 812.5

Hepatocyte Growth Factor (HGF) Antibody

abx323389-100g 100 µg
EUR 250

Hepatocyte Growth Factor (HGF) Antibody

abx323389-50g 50 µg
EUR 187.5

HGF Mouse Monoclonal Antibody

E10G34064 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HGF Rabbit Polyclonal Antibody

ES8380-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against HGF from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

HGF Rabbit Polyclonal Antibody

ES8380-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against HGF from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Hepatocyte Growth Factor (HGF) Antibody (APC)

20-abx274635
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Hepatocyte Growth Factor (HGF) Antibody (APC)

20-abx176818
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Hepatocyte Growth Factor (HGF) Antibody (APC)

abx274635-96tests 96 tests
EUR 412.5

Anti-Mouse HGF-R Antibody

103-M184 100 µg
EUR 399
Description: HGF R, also known as Met (from N-methyl-N-nitro-N-nitroso-guanidine induced), is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. This generates a mature HGF R that is a disulfidelinked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. The extracellular domain (ECD) contains a seven bladed β-propeller sema domain, a cysteine-rich PSI/MRS, and four Ig-like Eset domains, while the cytoplasmic region includes the tyrosine kinase domain. An alternately spliced form of mouse HGF R lacks a cytoplasmic juxtamembrane region important for regulation of signal transduction. The sema domain, which is formed by both the α and β chains of HGF R, mediates both ligand binding and receptor dimerization. Ligand-induced tyrosine phosphorylation in the cytoplasmic region activates the kinase domain and provides docking sites for multiple SH2containing molecules. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. In the absence of ligand, HGF R forms noncovalent complexes with a variety of membrane proteins including CD44v6, CD151, EGF R, Fas, integrin α6/β4, plexins B1, 2, 3, and MSP R/Ron (11 18). Ligation of one complex component triggers activation of the other, followed by cooperative signaling effects (11 18). Formation of some of these heteromeric complexes is a requirement for epithelial cell morphogenesis and tumor cell invasion. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells. Genetic polymorphisms, chromosomal translocation, overexpression, and additional splicing and proteolytic cleavage of HGF R have been described in a wide range of cancers. Within the ECD, mouse HGF R shares 87%, 87%, and 94% amino acid sequence identity with canine, human, and rat HGF R, respectively.

Anti-Human HGF-R Antibody

101-M450 100 µg
EUR 399
Description: HGF R, also known as Met (from N-methylN’ nitro-N-nitrosoguanidine induced), is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes co-translational proteolytic cleavage. This generates a mature HGF R that is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. The extracellular domain (ECD) contains a seven bladed β-propeller sema domain, a cysteine-rich PSI/MRS, and four Ig-like E-set domains, while the cytoplasmic region includes the tyrosine kinase domain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both the α and β chains of HGF R, mediates both ligand binding and receptor dimerization. Ligand-induced tyrosine phosphorylation in the cytoplasmic region activates the kinase domain and provides docking sites for multiple SH2-containing molecules. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. In the absence of ligand, HGF R forms noncovalent complexes with a variety of membrane proteins including CD44v6, CD151, EGF R, Fas, Integrin α6/β4, Plexins B1, 2, 3, and MSP R/Ron. Ligation of one complex component triggers activation of the other, followed by cooperative signaling effects. Formation of some of these heteromeric complexes is a requirement for epithelial cell morphogenesis and tumor cell invasion. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells. Genetic polymorphisms, chromosomal translocation, overexpression, and additional splicing and proteolytic cleavage of HGF R have been described in a wide range of cancers. Within the ECD, human HGF R shares 86-88% amino acid sequence identity with canine, mouse, and rat HGF R.

Hepatocyte Growth Factor (HGF) Antibody (FITC)

20-abx274174
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hepatocyte Growth Factor (HGF) Antibody Pair

20-abx370089
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  • 10 × 96 tests
  • 5 × 96 tests

Hepatocyte Growth Factor (HGF) Antibody (FITC)

20-abx273861
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hepatocyte Growth Factor (HGF) Antibody (FITC)

abx273861-50g 50 g
EUR 325

Hepatocyte Growth Factor (HGF) Antibody (FITC)

abx274174-05ml 0.5 ml
EUR 425

Hepatocyte Growth Factor (HGF) Antibody Pair

abx370089-100g 100 µg
EUR 987.5

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

20-abx271900
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

20-abx273129
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

ARP44319_P050-25UL - HGF Antibody - middle region

ARP44319_P050-25UL 25ul
EUR 99

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

abx271900-1ml 1 ml
EUR 537.5

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

abx271900-200l 200 µl
EUR 275

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

abx273129-25mg 25 mg
EUR 800

Hepatocyte Growth Factor (HGF) Antibody (Biotin)

abx273129-5mg 5 mg
EUR 362.5

ARP44319_P050 - HGF antibody - middle region (ARP44319_P050)

ARP44319_P050 100ul
EUR 389

Hepatocyte Growth Factor Antibody (HGF)

F45472-0.08ML 0.08 ml
EUR 140.25
Description: Hepatocyte Growth Factor is a potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. [UniProt]

Hepatocyte Growth Factor Antibody (HGF)

F40371-0.08ML 0.08 ml
EUR 140.25
Description: Hepatocyte Growth Factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 64-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq].

Hepatocyte Growth Factor Antibody (HGF)

V7839-100UG 100 ug
EUR 424.15
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

Hepatocyte Growth Factor Antibody (HGF)

V7839-20UG 20 ug
EUR 186.15
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

Hepatocyte Growth Factor Antibody (HGF)

V7839SAF-100UG 100 ug
EUR 424.15
Description: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

HGF rabbit polyclonal antibody, Purified

DP3519 200 µg Ask for price

HGF rabbit polyclonal antibody, Purified

DP3519S 100 µg Ask for price

HGF (521-554) rabbit polyclonal antibody, Purified

AP23835PU-N 200 µl Ask for price

ARP44317_P050-25UL - HGF Antibody - N-terminal region

ARP44317_P050-25UL 25ul
EUR 99

ARP44318_P050-25UL - HGF Antibody - N-terminal region

ARP44318_P050-25UL 25ul
EUR 99

OAAB12680-400UL - HGF Antibody - C-terminal region

OAAB12680-400UL 400ul
EUR 409

ARP44317_P050 - HGF antibody - N-terminal region (ARP44317_P050)

ARP44317_P050 100ul
EUR 389

ARP44318_P050 - HGF antibody - N-terminal region (ARP44318_P050)

ARP44318_P050 100ul
EUR 389

HGF rabbit polyclonal antibody, Aff - Purified

DP3519P 50 µg Ask for price

Hepatocyte Growth Factor (HGF) human, Antibody

GWB-C0E988 0.5 mg Ask for price

Monoclonal HGF Antibody (clone 7-2), Clone: 7-2

AMM01816G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human HGF (clone 7-2). The antibodies are raised in Mouse and are from clone 7-2. This antibody is applicable in WB and IHC-P

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28857-100ul 100ul
EUR 229.4

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28857-200ul 200ul
EUR 287.3

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28858-100ul 100ul
EUR 217.9

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28858-200ul 200ul
EUR 272.2

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28859-100ul 100ul
EUR 179

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28859-200ul 200ul
EUR 219

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28860-100ul 100ul
EUR 179

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28860-200ul 200ul
EUR 219

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28861-100ul 100ul
EUR 179

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28861-200ul 200ul
EUR 219

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28862-100ul 100ul
EUR 241.9

Hepatocyte Growth Factor (HGF) Polyclonal Antibody

CAU28862-200ul 200ul
EUR 302.4

Hepatocyte Growth Factor (HGF) Monoclonal Antibody

CAU30576-100ul 100ul
EUR 201.6

Hepatocyte Growth Factor (HGF) Monoclonal Antibody

CAU30576-200ul 200ul
EUR 252

Hepatocyte Growth Factor (HGF) Monoclonal Antibody

CAU29738-100ul 100ul
EUR 194.9

Hepatocyte Growth Factor (HGF) Monoclonal Antibody

CAU29738-200ul 200ul
EUR 243.6

Human HGF AssayLite™ Antibody (RPE Conjugate)

32740-05151 150 ug
EUR 370

Human HGF AssayLite™ Antibody (APC Conjugate)

32740-05161 150 ug
EUR 370

Human HGF AssayLite™ Antibody (FITC Conjugate)

32740-05141 150 ug
EUR 370

Genorise® Anti-canine HGF Polyclonal Antibody

GR105170 100 ug
EUR 438

Genorise® Anti-Equine HGF Polyclonal Antibody

GR105191 100 ug
EUR 438

Human HGF AssayLite™ Antibody (PerCP Conjugate)

32740-05171 150 ug
EUR 410

HGF (C-term) rabbit polyclonal antibody, Purified

AP11675PU-N 400 µl Ask for price

Monoclonal Antibody to Hepatocyte Growth Factor (HGF)

MAA047Hu22 100ul
EUR 203

Monoclonal Antibody to Hepatocyte Growth Factor (HGF)

MAA047Hu23 100ul
EUR 210

Monoclonal Antibody to Hepatocyte Growth Factor (HGF)

MAA047Ra21 100ul
EUR 253

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Ca01 100ul
EUR 252

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Hu01 100ul
EUR 160

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Hu02 100ul
EUR 160

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Hu03 100ul
EUR 160

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Mu01 100ul
EUR 227

Polyclonal Antibody to Hepatocyte Growth Factor (HGF)

PAA047Ra01 100ul
EUR 239

Recombinant Antibody to Hepatocyte Growth Factor (HGF)

RAA047Hu21 100ul
EUR 399

Hepatocyte Growth Factor (HGF) Polyclonal Antibody (Dog)

4-PAA047Ca01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Dog Hepatocyte Growth Factor (HGF)

Hepatocyte Growth Factor (HGF) Polyclonal Antibody (Rat)

4-PAA047Ra01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Hepatocyte Growth Factor (HGF)

Hepatocyte Growth Factor (HGF) Monoclonal Antibody (Human)

4-MAA047Hu22
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Hepatocyte Growth Factor (HGF)

Hepatocyte Growth Factor (HGF) Polyclonal Antibody (Human)

4-PAA047Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Hepatocyte Growth Factor (HGF)

Hepatocyte Growth Factor (HGF) Polyclonal Antibody (Human)

4-PAA047Hu02
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Hepatocyte Growth Factor (HGF)

Hepatocyte Growth Factor (HGF) Polyclonal Antibody (Human)

4-PAA047Hu03
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Hepatocyte Growth Factor (HGF)

These information show that BmK NSPK is a brand new voltage-gated potassium (Okayv) channel inhibitor that augments neurite extension through NGF/TrkA signaling pathway. Okayv channels could signify molecular targets to modulate SCN improvement and regeneration and to develop the therapies for spinal twine damage.

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