Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
Epithelial ovarian most cancers (EOC) is a deadly gynaecological neoplasm characterised by fast development and angiogenesis. Nerve development issue (NGF) and its excessive affinity receptor tropomyosin receptor kinase A (TRKA) contribute to EOC development by growing the expression of c-MYC, survivin and vascular endothelial development issue (VEGF) together with a lower in microRNAs (miR) 23b and 145. We beforehand reported that metformin prevents NGF-induced proliferation and angiogenic potential of EOC cells.
On this research, we sought to acquire a greater understanding of the mechanism(s) by which metformin blocks these NGF-induced results in EOC cells. Human ovarian floor epithelial (HOSE) and EOC (A2780/SKOV3) cells have been stimulated with NGF and/or metformin to evaluate the expression of c-MYC, β-catenin, survivin and VEGF and the abundance of the tumor suppressor miRs 23b and 145.
Metformin decreased the NGF-induced transcriptional exercise of MYC and β-catenin/T-cell issue/lymphoid enhancer-binding issue (TCF-Lef), in addition to the expression of c-MYC, survivin and VEGF in EOC cells, whereas it elevated miR-23b and miR-145 ranges. The preliminary evaluation of ovarian biopsies from ladies customers or non-users of metformin was per these in vitro outcomes. Our observations make clear the mechanisms by which metformin could suppress tumour development in EOC and counsel that metformin ought to be thought of as a potential complementary remedy in EOC remedy.
NGF/TRKA Lower miR-145-5p Ranges in Epithelial Ovarian Most cancers Cells
Nerve Development Issue (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) enhance their expression through the development of epithelial ovarian most cancers (EOC), selling cell proliferation and angiogenesis by a number of oncogenic proteins, akin to c-MYC and vascular endothelial development issue (VEGF). The expression of those proteins is managed by microRNAs (miRs), akin to miR-145, whose dysregulation has been associated to most cancers.
The goals of this work have been to judge in EOC cells whether or not NGF/TRKA decreases miR-145 ranges, and the impact of miR-145 upregulation. The degrees of miR-145-5p have been assessed by qPCR in ovarian biopsies and ovarian cell traces (human ovarian floor epithelial cells (HOSE), A2780 and SKOV3) stimulated with NGF. Overexpression of miR-145 in ovarian cells was used to judge cell proliferation, migration, invasion, c-MYC and VEGF protein ranges, in addition to tumor formation and metastasis in vivo.
In EOC samples, miR-145-5p ranges have been decrease than in epithelial ovarian tumors. Overexpression of miR-145 decreased cell proliferation, migration and invasion of EOC cells, modifications that have been concomitant with the lower in c-MYC and VEGF protein ranges. We noticed decreased tumor formation and suppressed metastasis conduct in mice injected with EOC cells that overexpressed miR-145. As anticipated, ovarian cell traces stimulated with NGF diminished miR-145-5p transcription and abundance. These outcomes counsel that the tumoral results of NGF/TRKA depend upon the regulation of miR-145-5p ranges in EOC cells, and that its upregulation might be used as a potential therapeutic technique for EOC.
Erinacine C Prompts Transcription from a Consensus ETS DNA Binding Website in Astrocytic Cells in Addition to NGF Induction
Medicinal mushrooms of the genus Hericium are recognized to supply secondary metabolites with homeostatic properties for the central nervous system. We and others have not too long ago demonstrated that amongst these metabolites cyathane diterpenoids and particularly erinacine C possess potent neurotrophin inducing properties in astrocytic cells. But, the signaling occasions downstream of erinacine C induced neurotrophin acitivity in neural-like adrenal phaeochromocytoma cells (PC12) cells have remained elusive.
Related, signaling occasions activated by erinacine C in astrocytic cells are unknown. Utilizing a mixture of genetic and pharmacological inhibitors we present that erinacine C induced neurotrophic exercise mediates PC12 cell differentiation by way of the TrkA receptor and certain its related PLCγ-, PI3K-, and MAPK/ERK pathways. Moreover, a small library of transcriptional activation reporters revealed that erinacine C induces transcriptional activation mediated by DNA consensus binding websites of chosen conserved transcription issue households.
Amongst these, transcription is activated from an ETS consensus in a focus dependent method. Apparently, induced ETS-consensus transcription happens in parallel and impartial of neurotrophin induction. This discovering helps to clarify the numerous pleiotropic features of cyathane diterpenoids. Furthermore, our research present genetic entry to cyathane diterpenoid features in astrocytic cells and assist to mechanistically perceive the motion of cyathanes in glial cells.
NGF-Induced Nav1.7 Upregulation Contributes to Continual Put up-surgical Ache by Activating SGK1-Dependent Nedd4-2 Phosphorylation
At current, power post-surgical ache (CPSP) is tough to stop and treatment clinically due to our lack of expertise of its mechanisms. Surgical harm induces the upregulation of voltage-gated sodium channel Nav1.7 in dorsal root ganglion (DRG) neurons, suggesting that Nav1.7 is concerned within the growth of CPSP. Nonetheless, the mechanism resulting in persistent dysregulation of Nav1.7 is basically unknown. On condition that nerve development issue (NGF) induces a long-term enhance within the neuronal hyperexcitability after harm, we hypothesized that NGF may trigger the long-term dysregulation of Nav1.7.
On this research, we aimed to research whether or not Nav1.7 regulation by NGF is concerned in CPSP and thus contributes to the precise mechanisms concerned within the growth of CPSP. Utilizing conditional nociceptor-specific Nav1.7 knockout mice, we confirmed the involvement of Nav1.7 in NGF-induced ache and recognized its function within the upkeep of ache conduct throughout long-term observations (as much as 14 days).
 *Mouse tPA Recombinant FITC Labeled |
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IMSTPARCFITC100UG |
Innovative research |
each |
EUR 559 |
|
|
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Description: *Mouse tPA Recombinant FITC Labeled |
*Mouse tPA Recombinant FITC Labeled |
|
IMSTPARCFITC50UG |
Innovative research |
each |
EUR 330 |
|
|
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Description: *Mouse tPA Recombinant FITC Labeled |
 *Human Fibrinogen Purified FITC Labeled |
|
IHUFBGFITC10MG |
Innovative research |
each |
EUR 114 |
|
|
|
Description: *Human Fibrinogen Purified FITC Labeled |
*Human Fibrinogen Purified FITC Labeled |
|
IHUFBGFITC50MG |
Innovative research |
each |
EUR 579 |
|
|
|
Description: *Human Fibrinogen Purified FITC Labeled |
 *Mouse Fibrinogen Purified FITC Labeled |
|
IMSFBGFITC10MG |
Innovative research |
each |
EUR 4974 |
|
|
|
Description: *Mouse Fibrinogen Purified FITC Labeled |
*Mouse Fibrinogen Purified FITC Labeled |
|
IMSFBGFITC1MG |
Innovative research |
each |
EUR 508 |
|
|
|
Description: *Mouse Fibrinogen Purified FITC Labeled |
 *Rabbit Fibrinogen Purified FITC Labeled |
|
IRBFBGFITC10MG |
Innovative research |
each |
EUR 254 |
|
|
|
Description: *Rabbit Fibrinogen Purified FITC Labeled |
*Rabbit Fibrinogen Purified FITC Labeled |
|
IRBFBGFITC40MG |
Innovative research |
each |
EUR 965 |
|
|
|
Description: *Rabbit Fibrinogen Purified FITC Labeled |
 *Bovine Fibrinogen Purified FITC Labeled |
|
IBOFBGFITC10MG |
Innovative research |
each |
EUR 163 |
|
|
|
Description: *Bovine Fibrinogen Purified FITC Labeled |
*Bovine Fibrinogen Purified FITC Labeled |
|
IBOFBGFITC40MG |
Innovative research |
each |
EUR 559 |
|
|
|
Description: *Bovine Fibrinogen Purified FITC Labeled |
 *Canine Fibrinogen Purified FITC Labeled |
|
ICNFBGFITC10MG |
Innovative research |
each |
EUR 5101 |
|
|
|
Description: *Canine Fibrinogen Purified FITC Labeled |
*Canine Fibrinogen Purified FITC Labeled |
|
ICNFBGFITC1MG |
Innovative research |
each |
EUR 640 |
|
|
|
Description: *Canine Fibrinogen Purified FITC Labeled |
 Ramos Cells , DNA Aptamer, FITC labeled |
|
AD-138-F |
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Custom |
Ask for price |
 Bovine Lactadherin Purified FITC Labeled |
|
IBOGCOLFITC1ML |
Innovative research |
each |
EUR 1307 |
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|
|
Description: Bovine Lactadherin Purified FITC Labeled |
 Bisphenol A, DNA Aptamer, FITC labeled |
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AD-108-F |
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, DNA Aptamer, FITC labeled) Daunomycin (10.10), DNA Aptamer, FITC labeled |
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AD-113-F |
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, DNA Aptamer, FITC labeled) Daunomycin (10.10v), DNA Aptamer, FITC labeled |
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AD-114-F |
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AD-150-F |
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, DNA Aptamer, FITC labeled) HGF (H38-15), DNA Aptamer, FITC labeled |
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AD-120-F |
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, DNA Aptamer, FITC labeled) Human IgE (4.4.12), DNA Aptamer, FITC labeled |
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AD-124-F |
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 , DNA Aptamer, FITC labeled) TGF-ß1 (T18_1_3) , DNA Aptamer, FITC labeled |
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AD-149-F |
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, DNA Aptamer, FITC labeled) Ethanolamine (14.3), DNA Aptamer, FITC labeled |
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AD-115-F |
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, DNA Aptamer, FITC labeled) Streptavidin (31), DNA Aptamer, FITC labeled |
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AD-144-F |
Alpha Diagnostics |
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 *Rabbit IgG Affinity Purified FITC Labeled |
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IRBIGGAPFITC1MG |
Innovative research |
each |
EUR 203 |
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|
|
Description: *Rabbit IgG Affinity Purified FITC Labeled |
, DNA Aptamer, FITC labeled) Cholic Acid (9), DNA Aptamer, FITC labeled |
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AD-111-F |
Alpha Diagnostics |
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, DNA Aptamer, FITC labeled) Ricin Toxin (C5), DNA Aptamer, FITC labeled |
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AD-139-F |
Alpha Diagnostics |
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 , DNA Aptamer, FITC labeled) Tetracyclines (T24) , DNA Aptamer, FITC labeled |
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AD-148-F |
Alpha Diagnostics |
Custom |
Ask for price |
 Human Soluble Fibrin Purified FITC Labeled |
|
IHUSFIBNFITC10MG |
Innovative research |
each |
EUR 1600 |
|
|
|
Description: Human Soluble Fibrin Purified FITC Labeled |
Human Soluble Fibrin Purified FITC Labeled |
|
IHUSFIBNFITC1MG |
Innovative research |
each |
EUR 200 |
|
|
|
Description: Human Soluble Fibrin Purified FITC Labeled |
 Hematoporphyrin IX , DNA Aptamer, FITC labeled |
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AD-117-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Human Plasminogen Glu Purified FITC Labeled |
|
IHUPLGFITC10MG |
Innovative research |
each |
EUR 1868 |
|
|
|
Description: *Human Plasminogen Glu Purified FITC Labeled |
*Human Plasminogen Glu Purified FITC Labeled |
|
IHUPLGFITC1MG |
Innovative research |
each |
EUR 234 |
|
|
|
Description: *Human Plasminogen Glu Purified FITC Labeled |
, DNA Aptamer, FITC labeled) Abrin Toxin (TA6), DNA Aptamer, FITC labeled |
|
AD-101-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) HIV-1 RT (4.3), DNA Aptamer, FITC labeled |
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AD-122-F |
Alpha Diagnostics |
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, DNA Aptamer, FITC labeled) CCRF-CEM (SGC8c), DNA Aptamer, FITC labeled |
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AD-109-F |
Alpha Diagnostics |
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, DNA Aptamer, FITC labeled) Cellobiose (Cel#16), DNA Aptamer, FITC labeled |
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AD-110-F |
Alpha Diagnostics |
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 , DNA Aptamer, FITC labeled) RNase H1 (VI-2) , DNA Aptamer, FITC labeled |
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AD-140-F |
Alpha Diagnostics |
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, DNA Aptamer, FITC labeled) Adenosine/ATP (DH25.42), DNA Aptamer, FITC labeled |
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AD-104-F |
Alpha Diagnostics |
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, DNA Aptamer, FITC labeled) Fibrinogen (85A/Ap90), DNA Aptamer, FITC labeled |
|
AD-116-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Human tPA Single Chain Purified FITC Labeled |
|
IHUTPASCFITC100UG |
Innovative research |
each |
EUR 442 |
|
|
|
Description: *Human tPA Single Chain Purified FITC Labeled |
*Human tPA Single Chain Purified FITC Labeled |
|
IHUTPASCFITC1MG |
Innovative research |
each |
EUR 3533 |
|
|
|
Description: *Human tPA Single Chain Purified FITC Labeled |
, DNA Aptamer, FITC labeled) L-Tyrosinamide (pe35), DNA Aptamer, FITC labeled |
|
AD-127-F |
Alpha Diagnostics |
Custom |
Ask for price |
 , DNA Aptamer, FITC labeled) Phospholamban (Apt-9) , DNA Aptamer, FITC labeled |
|
AD-135-F |
Alpha Diagnostics |
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 , DNA Aptamer, FITC labeled) Sialyllactose (Sl-11) , DNA Aptamer, FITC labeled |
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AD-141-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) Histone H4 (Clone 4.33), DNA Aptamer, FITC labeled |
|
AD-121-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) Anti-His-tag (6H7), DNA Aptamer, FITC labeled |
|
AD-105-F |
Alpha Diagnostics |
Custom |
Ask for price |
 Protein Kinase C-d , DNA Aptamer, FITC labeled |
|
AD-137-F |
Alpha Diagnostics |
Custom |
Ask for price |
 , DNA Aptamer, FITC labeled) Tenascin-C (GBI-10) , DNA Aptamer, FITC labeled |
|
AD-147-F |
Alpha Diagnostics |
Custom |
Ask for price |
 , DNA Aptamer, FITC labeled) Tumour Marker MUC1 (S1.1) , DNA Aptamer, FITC labeled |
|
AD-152-F |
Alpha Diagnostics |
Custom |
Ask for price |
, FITC Labeled) Goat anti-guinea pig IgG (H+L), FITC Labeled |
|
GP40100 |
Neuromics |
1.0 ml |
EUR 373.2 |
 , DNA Aptamer, FITC labeled) Taq DNA polymerase (TQ21) , DNA Aptamer, FITC labeled |
|
AD-146-F |
Alpha Diagnostics |
Custom |
Ask for price |
 , DNA Aptamer, FITC labeled) Staphylococcus aureus (SA23) , DNA Aptamer, FITC labeled |
|
AD-143-F |
Alpha Diagnostics |
Custom |
Ask for price |
 Purified FITC Labeled) *Human Receptor Associated (RAP) Purified FITC Labeled |
|
IHURAPFITC100UG |
Innovative research |
each |
EUR 249 |
|
|
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Description: *Human Receptor Associated (RAP) Purified FITC Labeled |
*Human Receptor Associated (RAP) Purified FITC Labeled |
|
IHURAPFITC500UG |
Innovative research |
each |
EUR 995 |
|
|
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Description: *Human Receptor Associated (RAP) Purified FITC Labeled |
, DNA Aptamer, FITC labeled) Human L-Selectin (LD201), DNA Aptamer, FITC labeled |
|
AD-126-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Human Factor IXa Purified Active Site FITC Labeled |
|
IHUFIXAFITC100UG |
Innovative research |
each |
EUR 406 |
|
|
|
Description: *Human Factor IXa Purified Active Site FITC Labeled |
, DNA Aptamer, FITC labeled) Reactive Green 19 (GR-30), DNA Aptamer, FITC labeled |
|
AD-130-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Sheep Anti Human Kininogen IgG Fraction FITC Labeled |
|
ISHAHUKNGFITC10MG |
Innovative research |
each |
EUR 2834 |
|
|
|
Description: *Sheep Anti Human Kininogen IgG Fraction FITC Labeled |
*Sheep Anti Human Kininogen IgG Fraction FITC Labeled |
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ISHAHUKNGFITC1MG |
Innovative research |
each |
EUR 359 |
|
|
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Description: *Sheep Anti Human Kininogen IgG Fraction FITC Labeled |
 *Innovative Grade US Origin Rat Fibrinogen FITC Labeled |
|
IRTFBGFITC10MG |
Innovative research |
each |
EUR 5025 |
|
|
|
Description: *Innovative Grade US Origin Rat Fibrinogen FITC Labeled |
*Innovative Grade US Origin Rat Fibrinogen FITC Labeled |
|
IRTFBGFITC1MG |
Innovative research |
each |
EUR 515 |
|
|
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Description: *Innovative Grade US Origin Rat Fibrinogen FITC Labeled |
, DNA Aptamer, FITC labeled) Lactobacillum acidophilius (hemag1P), DNA Aptamer, FITC labeled |
|
AD-125-F |
Alpha Diagnostics |
Custom |
Ask for price |
 Goat Anti Ferret IgG Polyclonal FITC Labeled Lyophilized |
|
IGTAFRIGGFITCLY1mg |
Innovative research |
each |
EUR 419 |
|
|
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Description: Goat Anti Ferret IgG Polyclonal FITC Labeled Lyophilized |
 Goat Anti Ferret IgM Polyclonal FITC Labeled Lyophilized |
|
IGTAFRIGMFITCLY1mg |
Innovative research |
each |
EUR 455 |
|
|
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Description: Goat Anti Ferret IgM Polyclonal FITC Labeled Lyophilized |
 *Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
|
ISHAHUTPAGFFITC100UG |
Innovative research |
each |
EUR 209 |
|
|
|
Description: *Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
|
ISHAHUTPAGFFITC10MG |
Innovative research |
each |
EUR 2580 |
|
|
|
Description: *Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
|
ISHAHUTPAGFFITC1MG |
Innovative research |
each |
EUR 347 |
|
|
|
Description: *Sheep Anti Human tPA Polyclonal Fractionated FITC Labeled |
 , DNA Aptamer, FITC labeled) Small-cell lung cancer (HCH07) , DNA Aptamer, FITC labeled |
|
AD-142-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
|
ISHARBTPAGFFITC100UG |
Innovative research |
each |
EUR 289 |
|
|
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Description: *Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
|
ISHARBTPAGFFITC10MG |
Innovative research |
each |
EUR 3017 |
|
|
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Description: *Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
|
ISHARBTPAGFFITC1MG |
Innovative research |
each |
EUR 481 |
|
|
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Description: *Sheep Anti Rabbit tPA Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human tPA Polyclonal Fractionated FITC Labeled |
|
IRBAHUTPAGFFITC1MG |
Innovative research |
each |
EUR 533 |
|
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Description: *Rabbit Anti Human tPA Polyclonal Fractionated FITC Labeled |
, DNA Aptamer, FITC labeled) Hepatitis C Virus RdRp (r10/43), DNA Aptamer, FITC labeled |
|
AD-119-F |
Alpha Diagnostics |
Custom |
Ask for price |
 , DNA Aptamer, FITC labeled) Human Neutrophil Elastase (DNA I) , DNA Aptamer, FITC labeled |
|
AD-155-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) Non-small Cell Lung Cancer (S6), DNA Aptamer, FITC labeled |
|
AD-129-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) Hen Egg White Lysozyme (lys11-2), DNA Aptamer, FITC labeled |
|
AD-118-F |
Alpha Diagnostics |
Custom |
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 , DNA Aptamer, FITC labeled) YPEN-1 Endothelial Cells (III.1) , DNA Aptamer, FITC labeled |
|
AD-154-F |
Alpha Diagnostics |
Custom |
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, DNA Aptamer, FITC labeled) Acute myeloid leukemia cells (KH1C12), DNA Aptamer, FITC labeled |
|
AD-102-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBARTPAI1GFFITC100UG |
Innovative research |
each |
EUR 320 |
|
|
|
Description: *Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBARTPAI1GFFITC10MG |
Innovative research |
each |
EUR 3454 |
|
|
|
Description: *Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBARTPAI1GFFITC1MG |
Innovative research |
each |
EUR 533 |
|
|
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Description: *Rabbit Anti Rat PAI-1 Polyclonal Fractionated FITC Labeled |
 Rabbit Anti V5 Tag Polyclonal Affinity Purified FITC Labeled |
|
IRBAV5TAPFITC100UG |
Innovative research |
each |
EUR 425 |
|
|
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Description: Rabbit Anti V5 Tag Polyclonal Affinity Purified FITC Labeled |
Rabbit Anti V5 Tag Polyclonal Affinity Purified FITC Labeled |
|
IRBAV5TAPFITC1MG |
Innovative research |
each |
EUR 1571 |
|
|
|
Description: Rabbit Anti V5 Tag Polyclonal Affinity Purified FITC Labeled |
 *Sheep Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
|
ISHAHUPAI1GFFITC1MG |
Innovative research |
each |
EUR 374 |
|
|
|
Description: *Sheep Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
ISHAMSTPAGFFITC100UG |
Innovative research |
each |
EUR 256 |
|
|
|
Description: *Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
ISHAMSTPAGFFITC10MG |
Innovative research |
each |
EUR 2580 |
|
|
|
Description: *Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
ISHAMSTPAGFFITC1MG |
Innovative research |
each |
EUR 427 |
|
|
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Description: *Sheep Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
 Goat Anti Mouse IgG Polyclonal Affinity Purified FITC Labeled |
|
IGTAMSIGGAPFITC1MG |
Innovative research |
each |
EUR 176 |
|
|
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Description: Goat Anti Mouse IgG Polyclonal Affinity Purified FITC Labeled |
 *Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
|
IGTARBPAI1GFFITC100UG |
Innovative research |
each |
EUR 335 |
|
|
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Description: *Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
*Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
|
IGTARBPAI1GFFITC10MG |
Innovative research |
each |
EUR 3454 |
|
|
|
Description: *Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
*Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
|
IGTARBPAI1GFFITC1MG |
Innovative research |
each |
EUR 560 |
|
|
|
Description: *Goat Anti Rabbit PAI-1 Polyclonal Fractionated FITC Labeled |
 Chicken Anti HA Tag Polyclonal Affinity Purified FITC Labeled |
|
ICHAHATAPFITC100UG |
Innovative research |
each |
EUR 425 |
|
|
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Description: Chicken Anti HA Tag Polyclonal Affinity Purified FITC Labeled |
Chicken Anti HA Tag Polyclonal Affinity Purified FITC Labeled |
|
ICHAHATAPFITC1MG |
Innovative research |
each |
EUR 1571 |
|
|
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Description: Chicken Anti HA Tag Polyclonal Affinity Purified FITC Labeled |
, DNA Aptamer, FITC labeled) DNAzymeMB (Part of Lysozyme Aptasensor), DNA Aptamer, FITC labeled |
|
AD-128-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAMSPAI1GFFITC100UG |
Innovative research |
each |
EUR 253 |
|
|
|
Description: *Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAMSPAI1GFFITC10MG |
Innovative research |
each |
EUR 3411 |
|
|
|
Description: *Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAMSPAI1GFFITC1MG |
Innovative research |
each |
EUR 422 |
|
|
|
Description: *Rabbit Anti Mouse PAI-1 Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
IRBAMSTPSGFFITC100UG |
Innovative research |
each |
EUR 317 |
|
|
|
Description: *Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
IRBAMSTPSGFFITC10MG |
Innovative research |
each |
EUR 4263 |
|
|
|
Description: *Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
|
IRBAMSTPSGFFITC1MG |
Innovative research |
each |
EUR 528 |
|
|
|
Description: *Rabbit Anti Mouse/Rat tPA Polyclonal Fractionated FITC Labeled |
 Rabbit Anti Goat IgG Polyclonal Affinity Purified FITC Labeled |
|
IRBAGTIGGAPFITC1MG |
Innovative research |
each |
EUR 155 |
|
|
|
Description: Rabbit Anti Goat IgG Polyclonal Affinity Purified FITC Labeled |
 Goat Anti Canine IgG Polyclonal Affinity Purified FITC Labeled |
|
IGTACNIGGAPFITC1MG |
Innovative research |
each |
EUR 260 |
|
|
|
Description: Goat Anti Canine IgG Polyclonal Affinity Purified FITC Labeled |
 *Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAHUPAI1GFFITC100UG |
Innovative research |
each |
EUR 320 |
|
|
|
Description: *Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAHUPAI1GFFITC10MG |
Innovative research |
each |
EUR 3326 |
|
|
|
Description: *Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
|
IRBAHUPAI1GFFITC1MG |
Innovative research |
each |
EUR 533 |
|
|
|
Description: *Rabbit Anti Human PAI-1 Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSFBNGFFITC100UG |
Innovative research |
each |
EUR 289 |
|
|
|
Description: *Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSFBNGFFITC10MG |
Innovative research |
each |
EUR 3017 |
|
|
|
Description: *Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSFBNGFFITC1MG |
Innovative research |
each |
EUR 481 |
|
|
|
Description: *Rabbit Anti Mouse Fibronectin Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSVTNGFFITC100UG |
Innovative research |
each |
EUR 384 |
|
|
|
Description: *Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSVTNGFFITC10MG |
Innovative research |
each |
EUR 3981 |
|
|
|
Description: *Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAMSVTNGFFITC1MG |
Innovative research |
each |
EUR 640 |
|
|
|
Description: *Rabbit Anti Mouse Vitronectin Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAMSAPLGFFITC100UG |
Innovative research |
each |
EUR 353 |
|
|
|
Description: *Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAMSAPLGFFITC10MG |
Innovative research |
each |
EUR 3981 |
|
|
|
Description: *Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAMSAPLGFFITC1MG |
Innovative research |
each |
EUR 587 |
|
|
|
Description: *Rabbit Anti Mouse Antiplasmin Polyclonal Fractionated FITC Labeled |
 Rabbit Anti Mouse Fibrinogen Polyclonal Fractionated FITC Labeled |
|
IRBAMSFBGGFFITC1MG |
Innovative research |
each |
EUR 550 |
|
|
|
Description: Rabbit Anti Mouse Fibrinogen Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Human Plasminogen Polyclonal Fractionated FITC Labeled |
|
ISHAHUPLGGFFITC1MG |
Innovative research |
each |
EUR 374 |
|
|
|
Description: *Sheep Anti Human Plasminogen Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
|
ISHAMSNSPGFFITC100UG |
Innovative research |
each |
EUR 304 |
|
|
|
Description: *Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
|
ISHAMSNSPGFFITC10MG |
Innovative research |
each |
EUR 2980 |
|
|
|
Description: *Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
|
ISHAMSNSPGFFITC1MG |
Innovative research |
each |
EUR 507 |
|
|
|
Description: *Sheep Anti Mouse Neuroserpin Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAHUAPLGFFITC100UG |
Innovative research |
each |
EUR 381 |
|
|
|
Description: *Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAHUAPLGFFITC10MG |
Innovative research |
each |
EUR 3981 |
|
|
|
Description: *Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
|
IRBAHUAPLGFFITC1MG |
Innovative research |
each |
EUR 635 |
|
|
|
Description: *Rabbit Anti Human Antiplasmin Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAHUVTNGFFITC100UG |
Innovative research |
each |
EUR 292 |
|
|
|
Description: *Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAHUVTNGFFITC10MG |
Innovative research |
each |
EUR 3981 |
|
|
|
Description: *Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
|
IRBAHUVTNGFFITC1MG |
Innovative research |
each |
EUR 486 |
|
|
|
Description: *Rabbit Anti Human Vitronectin Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human Fibrinogen Polyclonal Fractionated FITC Labeled |
|
IRBAHUFBGGFFITC1MG |
Innovative research |
each |
EUR 640 |
|
|
|
Description: *Rabbit Anti Human Fibrinogen Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human Fibronectin Polyclonal Fractionated FITC Labeled |
|
IRBAHUFBNGFFITC1MG |
Innovative research |
each |
EUR 427 |
|
|
|
Description: *Rabbit Anti Human Fibronectin Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
|
ISHAMSFIXGFFITC100UG |
Innovative research |
each |
EUR 221 |
|
|
|
Description: *Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
|
ISHAMSFIXGFFITC10MG |
Innovative research |
each |
EUR 2878 |
|
|
|
Description: *Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
|
ISHAMSFIXGFFITC1MG |
Innovative research |
each |
EUR 368 |
|
|
|
Description: *Sheep Anti Mouse Factor IX Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
|
ISHAMSFXGFFITC100UG |
Innovative research |
each |
EUR 317 |
|
|
|
Description: *Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
|
ISHAMSFXGFFITC10MG |
Innovative research |
each |
EUR 3326 |
|
|
|
Description: *Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
|
ISHAMSFXGFFITC1MG |
Innovative research |
each |
EUR 528 |
|
|
|
Description: *Sheep Anti Mouse Factor X Polyclonal Fractionated FITC Labeled |
 Purified High Molecular Weight FITC Labeled) *Human Urokinase (uPA) Purified High Molecular Weight FITC Labeled |
|
IHUUPAHMWFITC100UG |
Innovative research |
each |
EUR 503 |
|
|
|
Description: *Human Urokinase (uPA) Purified High Molecular Weight FITC Labeled |
*Human Urokinase (uPA) Purified High Molecular Weight FITC Labeled |
|
IHUUPAHMWFITC1MG |
Innovative research |
each |
EUR 3654 |
|
|
|
Description: *Human Urokinase (uPA) Purified High Molecular Weight FITC Labeled |
 Multivalent B-cell receptor specific, DNA apatamer, FITC labeled |
|
AD-156-F |
Alpha Diagnostics |
Custom |
Ask for price |
 *Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
|
ISHAHUFXIIGFFITC100UG |
Innovative research |
each |
EUR 173 |
|
|
|
Description: *Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
*Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
|
ISHAHUFXIIGFFITC10MG |
Innovative research |
each |
EUR 2303 |
|
|
|
Description: *Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
*Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
|
ISHAHUFXIIGFFITC1MG |
Innovative research |
each |
EUR 289 |
|
|
|
Description: *Sheep Anti Human Factor XII Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
|
ISHAMSPROCGFFITC100UG |
Innovative research |
each |
EUR 221 |
|
|
|
Description: *Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
|
ISHAMSPROCGFFITC10MG |
Innovative research |
each |
EUR 2878 |
|
|
|
Description: *Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
|
ISHAMSPROCGFFITC1MG |
Innovative research |
each |
EUR 368 |
|
|
|
Description: *Sheep Anti Mouse Protein C Polyclonal Fractionated FITC Labeled |
 *Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
|
IRBAHUFXGFFITC100UG |
Innovative research |
each |
EUR 320 |
|
|
|
Description: *Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
|
IRBAHUFXGFFITC10MG |
Innovative research |
each |
EUR 3326 |
|
|
|
Description: *Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
|
IRBAHUFXGFFITC1MG |
Innovative research |
each |
EUR 533 |
|
|
|
Description: *Rabbit Anti Human Factor X Polyclonal Fractionated FITC Labeled |
 *Mouse Anti Human 515 kDa LRP Monoclonal Clone 8G1 FITC Labeled |
|
IMSAHU515LRP8G1CFITC100UG |
Innovative research |
each |
EUR 240 |
|
|
|
Description: *Mouse Anti Human 515 kDa LRP Monoclonal Clone 8G1 FITC Labeled |
*Mouse Anti Human 515 kDa LRP Monoclonal Clone 8G1 FITC Labeled |
|
IMSAHU515LRP8G1CFITC1MG |
Innovative research |
each |
EUR 1919 |
|
|
|
Description: *Mouse Anti Human 515 kDa LRP Monoclonal Clone 8G1 FITC Labeled |
 *Mouse Anti Human 85 kDa LRP Monoclonal Clone 8B8 FITC Labeled |
|
IMSAHU85LRP8B8CFITC100UG |
Innovative research |
each |
EUR 240 |
|
|
|
Description: *Mouse Anti Human 85 kDa LRP Monoclonal Clone 8B8 FITC Labeled |
*Mouse Anti Human 85 kDa LRP Monoclonal Clone 8B8 FITC Labeled |
|
IMSAHU85LRP8B8CFITC1MG |
Innovative research |
each |
EUR 1919 |
|
|
|
Description: *Mouse Anti Human 85 kDa LRP Monoclonal Clone 8B8 FITC Labeled |
 *Mouse Anti Human 85 kDa LRP Monoclonal Clone 5A6 FITC Labeled |
|
IMSAHU85LRPFG5A6CFITC100UG |
Innovative research |
each |
EUR 240 |
|
|
|
Description: *Mouse Anti Human 85 kDa LRP Monoclonal Clone 5A6 FITC Labeled |
*Mouse Anti Human 85 kDa LRP Monoclonal Clone 5A6 FITC Labeled |
|
IMSAHU85LRPFG5A6CFITC1MG |
Innovative research |
each |
EUR 1919 |
|
|
|
Description: *Mouse Anti Human 85 kDa LRP Monoclonal Clone 5A6 FITC Labeled |
 *Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
|
IRBAPCFBGGFFITC100UG |
Innovative research |
each |
EUR 253 |
|
|
|
Description: *Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
|
IRBAPCFBGGFFITC10MG |
Innovative research |
each |
EUR 2361 |
|
|
|
Description: *Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
|
IRBAPCFBGGFFITC1MG |
Innovative research |
each |
EUR 422 |
|
|
|
Description: *Rabbit Anti Porcine Fibrinogen Polyclonal Fractionated FITC Labeled |
 *Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
|
ISHAMSTHPOGFFITC100UG |
Innovative research |
each |
EUR 225 |
|
|
|
Description: *Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
|
ISHAMSTHPOGFFITC10MG |
Innovative research |
each |
EUR 2985 |
|
|
|
Description: *Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
*Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
|
ISHAMSTHPOGFFITC1MG |
Innovative research |
each |
EUR 374 |
|
|
|
Description: *Sheep Anti Mouse Thrombopoietin Polyclonal Fractionated FITC Labeled |
 Crude Extracellular Mixture of E. coli, DNA Aptamer, FITC labeled |
|
AD-112-F |
Alpha Diagnostics |
Custom |
Ask for price |
 Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
|
IRBAMSFVIIGFFITC100UG |
Innovative research |
each |
EUR 312 |
|
|
|
Description: Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
|
IRBAMSFVIIGFFITC10MG |
Innovative research |
each |
EUR 4158 |
|
|
|
Description: Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
|
IRBAMSFVIIGFFITC1MG |
Innovative research |
each |
EUR 520 |
|
|
|
Description: Rabbit Anti Mouse Factor XII Polyclonal Fractionated FITC Labeled |
 Recombinant Low Molecular Weight FITC Labeled) *Human Urokinase (uPA) Recombinant Low Molecular Weight FITC Labeled |
|
IHUUPALMWRFITC100UG |
Innovative research |
each |
EUR 503 |
|
|
|
Description: *Human Urokinase (uPA) Recombinant Low Molecular Weight FITC Labeled |
*Human Urokinase (uPA) Recombinant Low Molecular Weight FITC Labeled |
|
IHUUPALMWRFITC1MG |
Innovative research |
each |
EUR 3654 |
|
|
|
Description: *Human Urokinase (uPA) Recombinant Low Molecular Weight FITC Labeled |
 *Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
|
IRBAHUFVIIFITC100UG |
Innovative research |
each |
EUR 320 |
|
|
|
Description: *Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
|
IRBAHUFVIIFITC10MG |
Innovative research |
each |
EUR 3326 |
|
|
|
Description: *Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
*Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
|
IRBAHUFVIIFITC1MG |
Innovative research |
each |
EUR 533 |
|
|
|
Description: *Rabbit Anti Human Factor VII Polyclonal Fractionated FITC Labeled |
Utilizing western blot analyses and immunostaining, we confirmed that NGF may set off the upregulation of Nav1.7 expression and thus help the event of CPSP in rats. Utilizing pharmacological approaches, we confirmed that the rise of Nav1.7 could be partly regulated by an NGF/TrkA-SGK1-Nedd4-2-mediated pathway. Moreover, reversing the upregulation of Nav1.7 in DRG may alleviate spinal sensitization. Our outcomes counsel that the maintained upregulation of Nav1.7 triggered by NGF contributes to the event of CPSP. Attenuating the dysregulation of Nav1.7 in peripheral nociceptors could also be a method to stop the transition from acute post-surgical ache to CPSP.
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