Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

Epithelial ovarian most cancers (EOC) is a deadly gynaecological neoplasm characterised by fast development and angiogenesis. Nerve development issue (NGF) and its excessive affinity receptor tropomyosin receptor kinase A (TRKA) contribute to EOC development by growing the expression of c-MYC, survivin and vascular endothelial development issue (VEGF) together with a lower in microRNAs (miR) 23b and 145. We beforehand reported that metformin prevents NGF-induced proliferation and angiogenic potential of EOC cells.

On this research, we sought to acquire a greater understanding of the mechanism(s) by which metformin blocks these NGF-induced results in EOC cells. Human ovarian floor epithelial (HOSE) and EOC (A2780/SKOV3) cells have been stimulated with NGF and/or metformin to evaluate the expression of c-MYC, β-catenin, survivin and VEGF and the abundance of the tumor suppressor miRs 23b and 145.

Metformin decreased the NGF-induced transcriptional exercise of MYC and β-catenin/T-cell issue/lymphoid enhancer-binding issue (TCF-Lef), in addition to the expression of c-MYC, survivin and VEGF in EOC cells, whereas it elevated miR-23b and miR-145 ranges. The preliminary evaluation of ovarian biopsies from ladies customers or non-users of metformin was per these in vitro outcomes. Our observations make clear the mechanisms by which metformin could suppress tumour development in EOC and counsel that metformin ought to be thought of as a potential complementary remedy in EOC remedy.

NGF/TRKA Lower miR-145-5p Ranges in Epithelial Ovarian Most cancers Cells

Nerve Development Issue (NGF) and its high-affinity receptor tropomyosin receptor kinase A (TRKA) enhance their expression through the development of epithelial ovarian most cancers (EOC), selling cell proliferation and angiogenesis by a number of oncogenic proteins, akin to c-MYC and vascular endothelial development issue (VEGF). The expression of those proteins is managed by microRNAs (miRs), akin to miR-145, whose dysregulation has been associated to most cancers.
The goals of this work have been to judge in EOC cells whether or not NGF/TRKA decreases miR-145 ranges, and the impact of miR-145 upregulation. The degrees of miR-145-5p have been assessed by qPCR in ovarian biopsies and ovarian cell traces (human ovarian floor epithelial cells (HOSE), A2780 and SKOV3) stimulated with NGF. Overexpression of miR-145 in ovarian cells was used to judge cell proliferation, migration, invasion, c-MYC and VEGF protein ranges, in addition to tumor formation and metastasis in vivo.
In EOC samples, miR-145-5p ranges have been decrease than in epithelial ovarian tumors. Overexpression of miR-145 decreased cell proliferation, migration and invasion of EOC cells, modifications that have been concomitant with the lower in c-MYC and VEGF protein ranges. We noticed decreased tumor formation and suppressed metastasis conduct in mice injected with EOC cells that overexpressed miR-145. As anticipated, ovarian cell traces stimulated with NGF diminished miR-145-5p transcription and abundance. These outcomes counsel that the tumoral results of NGF/TRKA depend upon the regulation of miR-145-5p ranges in EOC cells, and that its upregulation might be used as a potential therapeutic technique for EOC.

Erinacine C Prompts Transcription from a Consensus ETS DNA Binding Website in Astrocytic Cells in Addition to NGF Induction

Medicinal mushrooms of the genus Hericium are recognized to supply secondary metabolites with homeostatic properties for the central nervous system. We and others have not too long ago demonstrated that amongst these metabolites cyathane diterpenoids and particularly erinacine C possess potent neurotrophin inducing properties in astrocytic cells. But, the signaling occasions downstream of erinacine C induced neurotrophin acitivity in neural-like adrenal phaeochromocytoma cells (PC12) cells have remained elusive.
Related, signaling occasions activated by erinacine C in astrocytic cells are unknown. Utilizing a mixture of genetic and pharmacological inhibitors we present that erinacine C induced neurotrophic exercise mediates PC12 cell differentiation by way of the TrkA receptor and certain its related PLCγ-, PI3K-, and MAPK/ERK pathways. Moreover, a small library of transcriptional activation reporters revealed that erinacine C induces transcriptional activation mediated by DNA consensus binding websites of chosen conserved transcription issue households.
Amongst these, transcription is activated from an ETS consensus in a focus dependent method. Apparently, induced ETS-consensus transcription happens in parallel and impartial of neurotrophin induction. This discovering helps to clarify the numerous pleiotropic features of cyathane diterpenoids. Furthermore, our research present genetic entry to cyathane diterpenoid features in astrocytic cells and assist to mechanistically perceive the motion of cyathanes in glial cells.
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells

NGF-Induced Nav1.7 Upregulation Contributes to Continual Put up-surgical Ache by Activating SGK1-Dependent Nedd4-2 Phosphorylation

At current, power post-surgical ache (CPSP) is tough to stop and treatment clinically due to our lack of expertise of its mechanisms. Surgical harm induces the upregulation of voltage-gated sodium channel Nav1.7 in dorsal root ganglion (DRG) neurons, suggesting that Nav1.7 is concerned within the growth of CPSP. Nonetheless, the mechanism resulting in persistent dysregulation of Nav1.7 is basically unknown. On condition that nerve development issue (NGF) induces a long-term enhance within the neuronal hyperexcitability after harm, we hypothesized that NGF may trigger the long-term dysregulation of Nav1.7.
On this research, we aimed to research whether or not Nav1.7 regulation by NGF is concerned in CPSP and thus contributes to the precise mechanisms concerned within the growth of CPSP. Utilizing conditional nociceptor-specific Nav1.7 knockout mice, we confirmed the involvement of Nav1.7 in NGF-induced ache and recognized its function within the upkeep of ache conduct throughout long-term observations (as much as 14 days).

Daunomycin (10.10), DNA Aptamer, FITC labeled

AD-113-F Custom Ask for price

Daunomycin (10.10v), DNA Aptamer, FITC labeled

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Ethanolamine (14.3), DNA Aptamer, FITC labeled

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Pb(II) , DNA Aptamer, FITC labeled

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Ramos Cells , DNA Aptamer, FITC labeled

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Streptavidin (31), DNA Aptamer, FITC labeled

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PC12 Cells (Aptamer, FITC labeled17a) , DNA Aptamer, FITC labeled

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Cellobiose (Cel#16), DNA Aptamer, FITC labeled

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TGF-ß1 (T18_1_3) , DNA Aptamer, FITC labeled

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FITC-Labeled Bovine Type I Collagen Substrate

4001 1 mg/ml x 10 ml
EUR 338.55
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FITC-Labeled Bovine Type II Collagen Substrate

4002 1 mg/ml x 10 ml
EUR 403.8
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mAb mouse anti-monkey CD3 FITC-labeled

CT163 50 µg
EUR 347

Anti-His-tag (6H7), DNA Aptamer, FITC labeled

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mAb mouse anti-rat IFN-γ FITC-labeled

CT034 50 µg
EUR 260

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CT120 50 µg
EUR 260

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CT220 50 µg
EUR 260

mAb mouse anti-human IL-13 FITC-labeled

CT246 50 µg
EUR 260

CXCR4-Phycoerythrin Labeled

FC15004 100 Tests
EUR 448

Ret-Fluorescein Labeled

FC15016 100 Tests
EUR 448

Ret-Allophycocyanin Labeled

FC15017 100 Tests
EUR 448

BDNF-Allophycocyanin Labeled

FC15019 100 Tests
EUR 507

Fluorescent labeled siRNA

M1255-10
EUR 691

Fluorescent labeled siRNA

M1255-2
EUR 441

Fluorescent labeled siRNA

M1255-3
EUR 463

Fluorescent labeled siRNA

M1255-4
EUR 485

Fluorescent labeled siRNA

M1255-5
EUR 528

Fluorescent labeled siRNA

M1255-6
EUR 550

Fluorescent labeled siRNA

M1255-7
EUR 582

Fluorescent labeled siRNA

M1255-8
EUR 615

Fluorescent labeled siRNA

M1255-9
EUR 659

Acute myeloid leukemia cells (KH1C12), DNA Aptamer, FITC labeled

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DNAzymeMB (Part of Lysozyme Aptasensor), DNA Aptamer, FITC labeled

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Multivalent B-cell receptor specific, DNA apatamer, FITC labeled

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Goat anti-guinea pig IgG (H+L), FITC Labeled

GP40100 1.0 ml
EUR 311

Aleuria Aurantia Lectin (Aal)-FITC conjugate

AAL15-FITC 0.5 ml
EUR 225

Monoclonal Anti-Rat IgG1-FITC Conjugate

50126-FITC 0.5 ml
EUR 286

Concanavalin A Lectin (ConA)-FITC conjugate

CONA15-FITC 0.5 ml
EUR 286

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LCA15-FITC 0.5 ml
EUR 286

Rabbit Anti-Salmonella IgG-FITC conjugate

SLM11-FITC 0.5 ml
EUR 347

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SNA15-FITC 0.5 ml
EUR 286

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vaccinia virus?infected A549 cells (TV08) , DNA Aptamer, FITC labeled

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YPEN-1 Endothelial Cells (III.1) , DNA Aptamer, FITC labeled

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Advanced Glycation End Products (Clone 9), DNA Aptamer, FITC labeled

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FITC-labeled anti-Fc? RI? ?human IgE receptor) antibody (CRA1)

72-004 50ug Ask for price
Description: The FITC-labeled anti-Fc? RI? ?human IgE receptor) antibody (CRA1) is available in Europe and for worldwide shipping via Gentaur.

FITC-labeled anti-Fc? RI? ?human IgE receptor) antibody (CRA2)

72-008 50ug
EUR 401
Description: The FITC-labeled anti-Fc? RI? ?human IgE receptor) antibody (CRA2) is available in Europe and for worldwide shipping via Gentaur.

Recombinant CD19 Protein (Pro 20-Lys 291) [Fc] [FITC-Labeled]

VAng-1208Lsx-200g 200 µg
EUR 4999
Description: FITC-Labeled Human CD19, human IgG1 Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P15391-1)

Recombinant CD19 Protein (Pro 20-Lys 291) [Fc] [FITC-Labeled]

VAng-1208Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human CD19, human IgG1 Fc Tag, is expressed in HEK 293 cells. (Uniprot ID: P15391-1)

Recombinant CD19 Protein (Pro 20-Lys 291) [His] [FITC-Labeled]

VAng-1210Lsx-200g 200 µg
EUR 4999
Description: FITC-Labeled Human CD19, His Tag, is expressed in HEK 293 cells. (Uniprot ID: P15391-1)

Recombinant CD19 Protein (Pro 20-Lys 291) [His] [FITC-Labeled]

VAng-1210Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human CD19, His Tag, is expressed in HEK 293 cells. (Uniprot ID: P15391-1)

FITC-Labeled Human CD30 Protein (Phe 19-Lys 379) [His]

VAng-1260Lsx-200g 200 µg
EUR 5219
Description: FITC-Labeled Human CD30, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001234.2)

FITC-Labeled Human CD30 Protein (Phe 19-Lys 379) [His]

VAng-1260Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human CD30, His tag, is expressed in HEK 293 cells. (Uniprot ID: NP_001234.2)

FITC-Labeled Human ErbB3 Protein (Ser 20-Thr 643) [His]

VAng-1511Lsx-200g 200 µg
EUR 5219
Description: FITC-Labeled Human ErbB3 (Her3), His Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1)

FITC-Labeled Human ErbB3 Protein (Ser 20-Thr 643) [His]

VAng-1511Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human ErbB3 (Her3), His Tag, is expressed in HEK 293 cells. (Uniprot ID: P21860-1)

FITC-labeled Human TNFSF13B Protein (Ala 134-Leu 285) [Fc]

VAng-1605Lsx-200g 200 µg
EUR 3487
Description: FITC-labeled Human TNFSF13B, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH20674.1)

FITC-labeled Human TNFSF13B Protein (Ala 134-Leu 285) [Fc]

VAng-1605Lsx-25g 25 µg
EUR 848
Description: FITC-labeled Human TNFSF13B, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH20674.1)

FITC-Labeled Human Her2 Protein (Thr 23-Thr 652) [His]

VAng-1665Lsx-200g 200 µg
EUR 5219
Description: FITC-Labeled Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

FITC-Labeled Human Her2 Protein (Thr 23-Thr 652) [His]

VAng-1665Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Her2, His tag, is expressed in human 293 cells. (Uniprot ID: P04626-1)

FITC-Labeled Human MSLN Protein (Glu 296-Gly 580) [His]

VAng-2554Lsx-200g 200 µg
EUR 3487
Description: FITC-Labeled Human Mesothelin protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH09272.1)

FITC-Labeled Human MSLN Protein (Glu 296-Gly 580) [His]

VAng-2554Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Mesothelin protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH09272.1)

FITC-Labeled Human MSLN Protein (Glu 296-Gly 580) [Fc]

VAng-2555Lsx-200g 200 µg
EUR 3487
Description: FITC-Labeled Human Mesothelin protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: AAH09272.1)

FITC-Labeled Human MSLN Protein (Glu 296-Gly 580) [Fc]

VAng-2555Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Mesothelin protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: AAH09272.1)

FITC-Labeled Human CD22 Protein (Asp 20-Arg 687) [His]

VAng-2711Lsx-200g 200 µg
EUR 3487
Description: FITC-Labeled Human Siglec-2 (CD22) protein, His Tag, was expressed in human 293 cells. (Uniprot ID: P20273-1)

FITC-Labeled Human CD22 Protein (Asp 20-Arg 687) [His]

VAng-2711Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Siglec-2 (CD22) protein, His Tag, was expressed in human 293 cells. (Uniprot ID: P20273-1)

FITC-Labeled Human SLAMF7 Protein (Ser 23-Met 226) [His]

VAng-2742Lsx-200g 200 µg
EUR 3844
Description: Human SLAMF7 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH27867)

FITC-Labeled Human SLAMF7 Protein (Ser 23-Met 226) [His]

VAng-2742Lsx-25g 25 µg
EUR 848
Description: Human SLAMF7 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH27867)

Goat Anti-Mouse albumin IgG-FITC Conjugate

ALB11-FITC 100 ug
EUR 347

Goat Anti-Human albumin IgG-FITC Conjugate

ALBH13-FITC 100 ug
EUR 347

Recombinant (E.Coli) purified Protein G-FITC Conjugate

PRTG15-FITC 1 ml
EUR 202

Wheat germ agglutinin Lectin (WGA)-FITC conjugate

WGA15-FITC 0.5 ml
EUR 286

FGF R3-Fluorescein Labeled

FC15006 100 Tests
EUR 448

gp130/CD130-Phycoerythrin Labeled

FC15014 100 Tests
EUR 448

FGF-R2-Allophycocyanin Labeled

FC15015 100 Tests
EUR 448

Labeled Neg Control siRNA

M1257-1
EUR 311

Labeled siRNA Set E

M1272-1
EUR 985

Labeled siRNA Set F

M1273-1
EUR 1181

Monoclonal Anti-Adenovirus (many isotypes) IgG-FITC conjugate

ADV12-FITC 100 ul
EUR 469

Goat Anti-Mouse IgG (Fc) IgG-FITC Conjugate

40151-FITC 1 ml
EUR 225

Rabbit Anti-Luciferase (Photobacterium fischerii) IgG-FITC Conjugate

LUCF12-FITC 500 ul
EUR 384

Ricinus communis (castor bean) Agglutinin (RCA120)-FITC conjugate

RCA15-FITC 0.5 ml
EUR 225

Rabbit anti-Beta-Galactosidase (E. Coli) IgG-FITC conjugate

BGAL12-FITC 100 ul
EUR 347

Goat Anti-Adenovirus type 2, hexon IgG-FITC conjugate

ADV11-FITC 0.5 ml
EUR 408

Anti-Human CD44 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00052-FITC 25 Tests, 100 Tests, 200 Tests
EUR 130
Description: Mouse Monoclonal Human CD44 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD28 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00065-FITC 25 tests, 100 tests
EUR 131
Description: Mouse Monoclonal Human CD28 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD14 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00137-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD14 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD11b Monoclonal Antibody FITC Conjugated, Flow Validated

FC00144-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD11b Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD19 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00154-FITC 25 Tests, 100 Tests, 200 Tests
EUR 102
Description: Mouse Monoclonal human CD19 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD38 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00193-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD38 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD25 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00214-FITC 25 Tests, 100 Tests, 200 Tests
EUR 108
Description: Mouse Monoclonal human CD25 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD4 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00344-FITC 25 Tests, 100 Tests, 200 Tests
EUR 96
Description: Mouse Monoclonal human CD4 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD5 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00480-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD5 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD45 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00555-FITC 25 Tests, 100 Tests, 200 Tests
EUR 114
Description: Mouse Monoclonal human CD45 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD2 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00570-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD2 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD71 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00591-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD71 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD62L Monoclonal Antibody FITC Conjugated, Flow Validated

FC00652-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD62L Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD59 Monoclonal Antibody FITC Conjugated, Flow Validated

FC00914-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD59 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD81 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01281-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal Human CD81 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD117 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01335-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD117 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD16 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01408-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD16 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD32 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01450-FITC 25 Tests, 100 Tests, 200 Tests
EUR 120
Description: Mouse Monoclonal human CD32 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD31 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01513-FITC 25 Tests, 100 Tests, 200 Tests
EUR 130
Description: Mouse Monoclonal Human CD31 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD90 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01818-FITC 25 Tests, 100 Tests, 200 Tests
EUR 153
Description: Mouse Monoclonal human CD90 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD7 Monoclonal Antibody FITC Conjugated, Flow Validated

FC01974-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD7 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD235a Monoclonal Antibody FITC Conjugated, Flow Validated

FC02184-FITC 25ug, 100ug
EUR 140
Description: Mouse Monoclonal human CD235a Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD8 Monoclonal Antibody FITC Conjugated, Flow Validated

FC02236-FITC 25 Tests, 100 Tests, 200 Tests
EUR 96
Description: Mouse Monoclonal human CD8 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD13 Monoclonal Antibody FITC Conjugated, Flow Validated

FC02591-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD13 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated

FC02675-FITC 25 Tests, 100 Tests, 200 Tests
EUR 101
Description: Mouse Monoclonal human CD3 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD20 Monoclonal Antibody FITC Conjugated, Flow Validated

FC03780-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD20 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD161 Monoclonal Antibody FITC Conjugated, Flow Validated

FC03917-FITC 25 tests, 100 tests
EUR 160
Description: Mouse Monoclonal Human CD161 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD10 Monoclonal Antibody FITC Conjugated, Flow Validated

FC04065-FITC 25 Tests, 100 Tests, 200 Tests
EUR 125
Description: Mouse Monoclonal human CD10 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD3 Monoclonal Antibody FITC Conjugated, Flow Validated

FC04405-FITC 25 tests, 100 tests
EUR 96
Description: Mouse Monoclonal Human CD3 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD11a Monoclonal Antibody FITC Conjugated, Flow Validated

FC04466-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal Human CD11a Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD15 Monoclonal Antibody FITC Conjugated, Flow Validated

FC04535-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD15 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Human CD66b Monoclonal Antibody FITC Conjugated, Flow Validated

FC05978-FITC 25 tests, 100 tests
EUR 137
Description: Mouse Monoclonal Human CD66b Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD57 Monoclonal Antibody FITC Conjugated, Flow Validated

FC09548-FITC 25 Tests, 100 Tests, 200 Tests
EUR 140
Description: Mouse Monoclonal human CD57 Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Mouse Monoclonal Anti-Human IgG1 (Fc-region)-FITC conjugate

10121-FITC 0.5 ml
EUR 225

Mouse Monoclonal Anti-Human IgG2 (Fc-region)-FITC conjugate

10122-FITC 0.5 ml
EUR 225

Mouse Monoclonal Anti-Human IgG3 (Hinge-region)-FITC conjugate

10123-FITC 0.5 ml
EUR 286

Mouse Monoclonal Anti-Human IgG4 (Fc-region)-FITC conjugate

10124-FITC 0.5 ml
EUR 286

Goat Anti-Poliomyelitis Virus 1-3 IgG-FITC Conjugate

POLV13-FITC 0.5 ml
EUR 408

Goat Anti-Rubella virus (HPV77 strain) IgG-FITC conjugate

RUBL11-FITC 1 ml
EUR 347

Apple Stem Pitting Virus of PSAH PearIsolate, DNA Aptamer, FITC labeled

AD-107-F Custom Ask for price

Platelet-Derived Growth Factor B-chain (36t), DNA Aptamer, FITC labeled

AD-136-F Custom Ask for price

Human Glypican 3 Protein (Gln 25-His 559) [Fc] (FITC-Labeled)

VAng-1698Lsx-200g 200 µg
EUR 3487
Description: FITC-Labeled Human Glypican 3 (GPC3), Fc Tag, is expressed in human 293 cells. (Uniprot ID: P51654)

Human Glypican 3 Protein (Gln 25-His 559) [Fc] (FITC-Labeled)

VAng-1698Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Glypican 3 (GPC3), Fc Tag, is expressed in human 293 cells. (Uniprot ID: P51654)

Human Glypican 3 Protein (Gln 25-His 559) [His] (FITC-Labeled)

VAng-1700Lsx-200g 200 µg
EUR 3487
Description: FITC-Labeled Human Glypican 3 (GPC3), His tag, is expressed in human 293 cells. (Uniprot ID: P51654-1)

Human Glypican 3 Protein (Gln 25-His 559) [His] (FITC-Labeled)

VAng-1700Lsx-25g 25 µg
EUR 848
Description: FITC-Labeled Human Glypican 3 (GPC3), His tag, is expressed in human 293 cells. (Uniprot ID: P51654-1)

Rabbit Anti-Bovine Serum Albumin (BSA) protein IgG-FITC Conjugate

ALBB14-FITC 0.5 ml
EUR 347

Goat Anti-Poly-His (6xhis) (His-tag) IgG-FITC conjugate

HISP16-FITC 100 ul
EUR 347

Goat Anti-Glutathione Transferase (GST, S. japonicum) IgG-FITC Conjugate

GST13-FITC 100 ul
EUR 347

Goat Anti-Hemeagglutinin fusion epitope (HA-tag) IgG-FITC conjugate

HA12-FITC 100 ug
EUR 347

Anti-human HLA-DR Monoclonal Antibody FITC Conjugated, Flow Validated

FC00568-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human HLA-DR Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human CD55/Daf Monoclonal Antibody FITC Conjugated, Flow Validated

FC00910-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human CD55/Daf Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-Mouse TCR beta Monoclonal Antibody FITC Conjugated, Flow Validated

FC09166-FITC 25 ug, 100ug, 500ug
EUR 91
Description: Hamster Monoclonal Mouse TCR beta Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Mouse.

Anti-Human HLA-ABC Monoclonal Antibody FITC Conjugated, Flow Validated

FC20056-FITC 25 Tests , 100 Tests , 200 Tests
EUR 137
Description: Mouse Monoclonal Human HLA-ABC Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.
Utilizing western blot analyses and immunostaining, we confirmed that NGF may set off the upregulation of Nav1.7 expression and thus help the event of CPSP in rats. Utilizing pharmacological approaches, we confirmed that the rise of Nav1.7 could be partly regulated by an NGF/TrkA-SGK1-Nedd4-2-mediated pathway. Moreover, reversing the upregulation of Nav1.7 in DRG may alleviate spinal sensitization. Our outcomes counsel that the maintained upregulation of Nav1.7 triggered by NGF contributes to the event of CPSP. Attenuating the dysregulation of Nav1.7 in peripheral nociceptors could also be a method to stop the transition from acute post-surgical ache to CPSP.

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