Aria Neurosciences

EXPRESS: Differentiation of the 50B11 dorsal root cells into NGF and GDNF responsive nociceptor subtypes

The embryonic rat dorsal root ganglion (DRG) neuron-derived 50B11 cell line is a promising sensory neuron mannequin expressing markers attribute of NGF and GDNF-dependent C-fibre nociceptors. Whether or not these cells have the capability to turn into distinct nociceptive subtypes primarily based on NGF- or GDNF-dependence has not been investigated.

Right here we present that by augmenting forskolin (FSK) and progress issue supplementation with NGF or GDNF, 50B11 cultures could be pushed to accumulate differential practical responses to frequent nociceptive agonists capsaicin and ATP respectively. As well as, to earlier research, we additionally show {that a} differentiated neuronal phenotype could be maintained for as much as 7 days.

Western blot evaluation of nociceptive marker proteins additional demonstrates that the 50B11 cells partially recapitulate the practical phenotypes of classical NGF-dependent (peptidergic) and GDNF-dependent (non-peptidergic) neuronal subtypes described in DRGs. Additional, 50B11 cells differentiated with NGF/FSK, however not GDNF/FSK, present sensitization to acute prostaglandin E2 therapy.

Lastly, RNA-Seq evaluation confirms that differentiation with NGF/FSK or GDNF/FSK produces two 50B11 cell subtypes with distinct transcriptome expression profiles. Gene ontology comparability of the 2 subtypes of differentiated 50B11 cells to rodent DRG neurons research exhibits vital overlap in matching or partially matching classes.

This transcriptomic evaluation will help future suitability evaluation of the 50B11 cells as a high-throughput nociceptor mannequin for a broad vary of experimental purposes. In conclusion, this examine exhibits that the 50B11 cell line is able to partially recapitulating options of two distinct forms of embryonic NGF and GDNF-dependent nociceptor-like cells.

A human related combination of persistent natural pollution (POPs) and perfluorooctane sulfonic acid (PFOS) improve nerve progress issue (NGF)-induced neurite outgrowth in PC12 cells

Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent natural pollution (POPs) are potential developmental neurotoxicants. We investigated their impact on neurite outgrowth in PC12 rat pheochromocytoma cells, in absence or presence of nerve progress issue (NGF), an inducer of neuronal differentiation. Cells had been uncovered for 72 h to an outlined combination of POPs with chemical composition and concentrations primarily based on blood ranges within the Scandinavian inhabitants.

We additionally evaluated perfluorooctane sulfonic acid (PFOS) alone, probably the most ample compound within the POP combination. Solely excessive concentrations of POP combination lowered tetrazolium salt (MTT) conversion. Excessive-content evaluation confirmed a lower in cell quantity, however no modifications for nuclear and mitochondrial mobile well being parameters.

Sturdy glutathione ranges had been noticed in NGF-differentiated cells. Stay imaging, utilizing the IncuCyte ZOOM platform indicated ongoing cell proliferation over time, however slower in presence of NGF. The pollution didn’t inhibit neuritogenesis, however somewhat elevated NGF-induced neurite size. PFOS induced neurite outgrowth to about 50% of the extent seen with the POP combination. Neither the POP combination nor PFOS affected neurite size within the absence of NGF. Our observations point out that lifelike advanced mixtures of environmental pollution can have an effect on neuronal connectivity by way of NGF-induced neurite outgrowth.

The biased ligands NGF and NT-Three differentially stabilize Trk-A dimers

Trk-A is a receptor tyrosine kinase (RTK) which performs an important position within the growth and functioning of the nervous system. Trk-A is expressed in neurons and alerts in response to 2 ligands, NGF and NT-3, with very totally different practical penalties. Thus, NGF and NT-Three are “biased” ligands for Trk-A. Because it has been hypothesized that biased RTK ligands induce differential stabilization of RTK dimers, right here we search to check this speculation for NGF and NT-3.

Particularly, we use Förster Resonance Power Switch (FRET) and Fluorescence Depth Fluctuation (FIF) spectroscopy to evaluate the energy of Trk-A interactions and Trk-A oligomer measurement within the presence of the 2 ligands. Whereas the distinction in Trk-A conduct in response to the 2 ligands has been beforehand attributed to variations of their binding to Trk-A within the endosomes at low pH, right here we additional present variations within the stabilities of the NGF and NT-Three certain Trk-A dimers within the plasma membrane and at impartial pH. We talk about the organic significance of those new findings and their implications for the design of Trk-A ligands with novel functionalities.

Results of NGF and BDNF on chondrocytes: a microarray evaluation

Osteoarthritis (OA) represents an inflammation-driven harm of articular tissues, progressively resulting in structural and practical joint impairment. The principle symptom of OA is ache. Though it has been nicely established that OA represents a complete joint illness, the supply of ache stays to be clarified. These days, it has been nicely established that neurotrophines expression is obvious in joints affected by OA. As well as, elevated NGF ranges are discovered within the synovial fluid of sufferers with inflammatory or degenerative rheumatic ailments, together with OA, rheumatoid arthritis and spondylarthritis.

Rising evidences point out that blocking NGF signaling utilizing an anti NGF agent (i.e. tanezumab) offers efficient ache aid. This examine analyzed the consequences of NGF and BDNF on cultured human chondrocytes by evaluating and their results on chondrogenesis, chondrocyte differentiation and cartilage degeneration by a microarray evaluation. The entire transcriptome evaluation carried out on this examine highlighted how NGF and BDNF may be capable to induce a proinflammatory response in human chondrocytes. Furthermore, NGF and BDNF remedies appears to have the ability to induce the activation of a number of genes concerned within the OA pathogenesis as IL17AR, HLA-DRB1, GDF-15, NR1D1, MCF2L and TGF-Beta.

Potential position of NGF, BDNF and their receptors in Oligodendrocytes differentiation from neural stem cell – an in-vitro examine

Neural stem cells (NSCs) or neuronal progenitor cells (NPCs) are cells able to differentiating into oligodendrocytes, myelin-forming cells which have the potential of remyelination. Mind-derived neurotrophic issue (BDNF) and Nerve progress issue (NGF) are two neurotrophic components which were studied to stimulate NSC differentiation thus taking part in a job in MS (A number of Sclerosis) pathogenesis and a number of other different demyelinating issues. Whereas a number of research have demonstrated the proliferative and protecting capabilities of those neurotrophic components, their mobile and molecular features are nonetheless not nicely understood.

Thus within the current examine we concentrate on understanding the position of those neurotrophins (BDNF and NGF) in oligodendrogenesis from NSCs. Each neurotrophic components have proven to advertise NSC proliferation and NSC differentiation significantly into oligodendroglial lineage in a dose dependent trend. Additional, to determine the position of those neurotrophins in NSC differentiation, we’ve got employed pharmacological inhibitors for TrkA and TrkB receptors in NSCs.

Using these inhibitors suppressed NSC differentiation into oligodendrocytes together with the down-regulation of phosphorylated ERK suggesting energetic involvement of ERK in functioning of those neurotrophins.

NGF Polyclonal Antibody
41239-100ul	SAB	100ul	EUR 302.4

NGF Polyclonal Antibody
41239-50ul	SAB	50ul	EUR 224.4

NGF Polyclonal Antibody
41931	SAB	100ul	EUR 319

NGF Polyclonal Antibody
41931-100ul	SAB	100ul	EUR 302.4

NGF Polyclonal Antibody
41931-50ul	SAB	50ul	EUR 224.4

NGF Polyclonal Antibody
E041239	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E041931	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E20-75565	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E90095A	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E913922	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E914216	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

NGF Polyclonal Antibody
E20-73114	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

Ngf Polyclonal Antibody
A52042	EpiGentek	Ask for price Ask for price Ask for price Ask for price	100 µg 20 ul 50 ul 100 ul

NGF Polyclonal Antibody
E-AB-93105-120uL	Elabscience Biotech	120uL	EUR 320
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-93105-200uL	Elabscience Biotech	200uL	EUR 530
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-93105-60uL	Elabscience Biotech	60uL	EUR 200
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-93105-each	Elabscience Biotech	each	Ask for price
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-14245-120uL	Elabscience Biotech	120uL	EUR 240
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-14245-200uL	Elabscience Biotech	200uL	EUR 399
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-14245-20uL	Elabscience Biotech	20uL	EUR 73
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-14245-60uL	Elabscience Biotech	60uL	EUR 143
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-10487-120uL	Elabscience Biotech	120uL	EUR 240
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-10487-200uL	Elabscience Biotech	200uL	EUR 399
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-10487-20uL	Elabscience Biotech	20uL	EUR 73
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-10487-60uL	Elabscience Biotech	60uL	EUR 143
Description: Unconjugated

NGF Polyclonal Antibody
MBS125020-002mL	MyBiosource	0.02mL	EUR 200

NGF Polyclonal Antibody
MBS125020-005mL	MyBiosource	0.05mL	EUR 255

NGF Polyclonal Antibody
MBS125020-01mL	MyBiosource	0.1mL	EUR 345

NGF Polyclonal Antibody
MBS125020-02mL	MyBiosource	0.2mL	EUR 545

NGF Polyclonal Antibody
MBS125020-5x02mL	MyBiosource	5x0.2mL	EUR 2265

NGF Polyclonal Antibody
A73313	EpiGentek	50 μl	EUR 557

NGF Polyclonal Antibody
BT-AP06007-100ul	Jiaxing Korain Biotech Ltd (BT Labs)	100ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
BT-AP06007-20ul	Jiaxing Korain Biotech Ltd (BT Labs)	20ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
BT-AP06007-50ul	Jiaxing Korain Biotech Ltd (BT Labs)	50ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
BT-AP06008-100ul	Jiaxing Korain Biotech Ltd (BT Labs)	100ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
BT-AP06008-20ul	Jiaxing Korain Biotech Ltd (BT Labs)	20ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
BT-AP06008-50ul	Jiaxing Korain Biotech Ltd (BT Labs)	50ul	Ask for price
Description: NGF is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. Nerve growth factorp has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in NGF have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
E44H07007	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Polyclonal Antibody
E44H02901	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Polyclonal Antibody
E-AB-32239-120uL	Elabscience Biotech	120uL	EUR 240
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-32239-200uL	Elabscience Biotech	200uL	EUR 399
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-32239-20uL	Elabscience Biotech	20uL	EUR 73
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-32239-60uL	Elabscience Biotech	60uL	EUR 143
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-40051-120uL	Elabscience Biotech	120uL	EUR 230
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-40051-200uL	Elabscience Biotech	200uL	EUR 380
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-40051-20uL	Elabscience Biotech	20uL	EUR 65
Description: Unconjugated

NGF Polyclonal Antibody
E-AB-40051-60uL	Elabscience Biotech	60uL	EUR 125
Description: Unconjugated

NGF Polyclonal Antibody
MBS9244509-01mL	MyBiosource	0.1mL	EUR 415

NGF Polyclonal Antibody
MBS9244509-5x01mL	MyBiosource	5x0.1mL	EUR 1841

NGF Polyclonal Antibody
MBS9246181-01mL	MyBiosource	0.1mL	EUR 415

NGF Polyclonal Antibody
MBS9246181-5x01mL	MyBiosource	5x0.1mL	EUR 1841

NGF Polyclonal Antibody
MBS9409294-005mL	MyBiosource	0.05mL	EUR 245

NGF Polyclonal Antibody
MBS9409294-01mL	MyBiosource	0.1mL	EUR 305

NGF Polyclonal Antibody
MBS9409294-5x01mL	MyBiosource	5x0.1mL	EUR 1230

NGF Polyclonal Antibody
MBS9408290-005mL	MyBiosource	0.05mL	EUR 245

NGF Polyclonal Antibody
MBS9408290-01mL	MyBiosource	0.1mL	EUR 305

NGF Polyclonal Antibody
MBS9408290-5x01mL	MyBiosource	5x0.1mL	EUR 1230

NGF Polyclonal Antibody
MBS9134225-002mL	MyBiosource	0.02mL	EUR 200

NGF Polyclonal Antibody
MBS9134225-005mL	MyBiosource	0.05mL	EUR 255

NGF Polyclonal Antibody
MBS9134225-01mL	MyBiosource	0.1mL	EUR 345

NGF Polyclonal Antibody
MBS9134225-02mL	MyBiosource	0.2mL	EUR 545

NGF Polyclonal Antibody
MBS9134225-5x02mL	MyBiosource	5x0.2mL	EUR 2265

NGF Polyclonal Antibody
MBS9133933-002mL	MyBiosource	0.02mL	EUR 200

NGF Polyclonal Antibody
MBS9133933-005mL	MyBiosource	0.05mL	EUR 255

NGF Polyclonal Antibody
MBS9133933-01mL	MyBiosource	0.1mL	EUR 345

NGF Polyclonal Antibody
MBS9133933-02mL	MyBiosource	0.2mL	EUR 545

NGF Polyclonal Antibody
MBS9133933-5x02mL	MyBiosource	5x0.2mL	EUR 2265

NGF Polyclonal Antibody
MBS8568628-01mL	MyBiosource	0.1mL	EUR 305

NGF Polyclonal Antibody
MBS8568628-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

NGF Polyclonal Antibody
MBS8568628-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

NGF Polyclonal Antibody
MBS8568628-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

NGF Polyclonal Antibody
MBS8568628-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

NGF Polyclonal Antibody
MBS8568907-01mL	MyBiosource	0.1mL	EUR 305

NGF Polyclonal Antibody
MBS8568907-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

NGF Polyclonal Antibody
MBS8568907-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

NGF Polyclonal Antibody
MBS8568907-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

NGF Polyclonal Antibody
MBS8568907-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

NGF Polyclonal Antibody
MBS8527312-01mg	MyBiosource	0.1mg	EUR 325

NGF Polyclonal Antibody
MBS8527312-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

NGF Polyclonal Antibody
MBS8527312-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

NGF Polyclonal Antibody
MBS8527312-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

NGF Polyclonal Antibody
MBS8527312-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

NGF Polyclonal Antibody
MBS8526546-01mg	MyBiosource	0.1mg	EUR 305

NGF Polyclonal Antibody
MBS8526546-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

NGF Polyclonal Antibody
MBS8526546-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

NGF Polyclonal Antibody
MBS8526546-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

NGF Polyclonal Antibody
MBS8526546-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

NGF Polyclonal Antibody
MBS8524095-01mg	MyBiosource	0.1mg	EUR 305

NGF Polyclonal Antibody
MBS8524095-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

NGF Polyclonal Antibody
MBS8524095-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

NGF Polyclonal Antibody
MBS8524095-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

NGF Polyclonal Antibody
MBS8524095-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

NGF Polyclonal Antibody
MBS2518027-002mL	MyBiosource	0.02mL	EUR 135

NGF Polyclonal Antibody
MBS2518027-006mL	MyBiosource	0.06mL	EUR 190

NGF Polyclonal Antibody
MBS2518027-012mL	MyBiosource	0.12mL	EUR 265

NGF Polyclonal Antibody
MBS2518027-02mL	MyBiosource	0.2mL	EUR 415

NGF Polyclonal Antibody
MBS2518027-5x02mL	MyBiosource	5x0.2mL	EUR 1835

NGF Polyclonal Antibody
MBS2538871-002mL	MyBiosource	0.02mL	EUR 135

NGF Polyclonal Antibody
MBS2538871-006mL	MyBiosource	0.06mL	EUR 190

NGF Polyclonal Antibody
MBS2538871-012mL	MyBiosource	0.12mL	EUR 265

NGF Polyclonal Antibody
MBS2538871-02mL	MyBiosource	0.2mL	EUR 415

NGF Polyclonal Antibody
MBS2538871-5x02mL	MyBiosource	5x0.2mL	EUR 1835

NGF Polyclonal Antibody
MBS2539537-002mL	MyBiosource	0.02mL	EUR 140

NGF Polyclonal Antibody
MBS2539537-006mL	MyBiosource	0.06mL	EUR 180

NGF Polyclonal Antibody
MBS2539537-012mL	MyBiosource	0.12mL	EUR 260

NGF Polyclonal Antibody
MBS2539537-02mL	MyBiosource	0.2mL	EUR 405

NGF Polyclonal Antibody
MBS2541746-002mL	MyBiosource	0.02mL	EUR 130

NGF Polyclonal Antibody
MBS2541746-006mL	MyBiosource	0.06mL	EUR 175

NGF Polyclonal Antibody
MBS2541746-012mL	MyBiosource	0.12mL	EUR 255

NGF Polyclonal Antibody
MBS2541746-02mL	MyBiosource	0.2mL	EUR 380

NGF Polyclonal Antibody
MBS2541746-5x02mL	MyBiosource	5x0.2mL	EUR 1675

NGF Polyclonal Antibody
MBS2526117-002mL	MyBiosource	0.02mL	EUR 135

NGF Polyclonal Antibody
MBS2526117-006mL	MyBiosource	0.06mL	EUR 190

NGF Polyclonal Antibody
MBS2526117-012mL	MyBiosource	0.12mL	EUR 265

NGF Polyclonal Antibody
MBS2526117-02mL	MyBiosource	0.2mL	EUR 415

NGF Polyclonal Antibody
MBS2526117-5x02mL	MyBiosource	5x0.2mL	EUR 1835

NGF Polyclonal Antibody
RD77529A-120uL	Reddot Biotech	120μL	EUR 360
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD77529A-200uL	Reddot Biotech	200μL	EUR 630
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD77529A-20uL	Reddot Biotech	20μL	EUR 109.5
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD77529A-60uL	Reddot Biotech	60μL	EUR 214.5
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD240051A-120uL	Reddot Biotech	120μL	EUR 345
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD240051A-200uL	Reddot Biotech	200μL	EUR 570
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD240051A-20uL	Reddot Biotech	20μL	EUR 97.5
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD240051A-60uL	Reddot Biotech	60μL	EUR 187.5
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD71549A-120uL	Reddot Biotech	120μL	EUR 360
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD71549A-200uL	Reddot Biotech	200μL	EUR 630
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD71549A-20uL	Reddot Biotech	20μL	EUR 109.5
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD71549A-60uL	Reddot Biotech	60μL	EUR 214.5
Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.

NGF Polyclonal Antibody
RD75289A-120uL	Reddot Biotech	120μL	EUR 360
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD75289A-200uL	Reddot Biotech	200μL	EUR 630
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD75289A-20uL	Reddot Biotech	20μL	EUR 109.5
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
RD75289A-60uL	Reddot Biotech	60μL	EUR 214.5
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

NGF Polyclonal Antibody
UB-GEN-12579	UpingBio	100 ul	EUR 200

NGF (L82) polyclonal antibody
E43S3564	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

NGF goat polyclonal antibody
GT15014-100	Origene Technologies GmbH	100 µg	Ask for price

NGF Rabbit Polyclonal Antibody
ES2958-100ul	ELK Biotech	100ul	EUR 124
Description: A Rabbit Polyclonal antibody against NGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NGF Rabbit Polyclonal Antibody
ES2958-50ul	ELK Biotech	50ul	EUR 74
Description: A Rabbit Polyclonal antibody against NGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NGF Rabbit Polyclonal Antibody
ES4295-100ul	ELK Biotech	100ul	EUR 124
Description: A Rabbit Polyclonal antibody against NGF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NGF Rabbit Polyclonal Antibody
ES4295-50ul	ELK Biotech	50ul	EUR 74
Description: A Rabbit Polyclonal antibody against NGF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

NGF Rabbit Polyclonal Antibody
E10G23168	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Rabbit Polyclonal Antibody
E10G23528	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Rabbit Polyclonal Antibody
E10G00563	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Rabbit Polyclonal Antibody
E10G03743	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Rabbit Polyclonal Antibody
E10G10675	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Rabbit Polyclonal Antibody
E10G07482	EnoGene	100 μl	EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NGF Polyclonal Antibody, HRP Conjugated
A64863	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

Ngf Polyclonal Antibody, HRP Conjugated
A52043	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

NGF Polyclonal Antibody, FITC Conjugated
A64864	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

Ngf Polyclonal Antibody, FITC Conjugated
A52044	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

NGF Polyclonal Antibody, Biotin Conjugated
A64865	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

Ngf Polyclonal Antibody, Biotin Conjugated
A52045	EpiGentek	Ask for price Ask for price Ask for price	100 µg 50 ul 100 ul

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU28597-100ul	Biomatik Corporation	100ul	EUR 207.4

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU28597-200ul	Biomatik Corporation	200ul	EUR 258.7

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU28598-100ul	Biomatik Corporation	100ul	EUR 188.2

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU28598-200ul	Biomatik Corporation	200ul	EUR 235.2

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30941-100ul	Biomatik Corporation	100ul	EUR 254.4

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30941-200ul	Biomatik Corporation	200ul	EUR 317.5

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30942-100ul	Biomatik Corporation	100ul	EUR 241.9

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30942-200ul	Biomatik Corporation	200ul	EUR 302.4

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30943-100ul	Biomatik Corporation	100ul	EUR 254.4

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30943-200ul	Biomatik Corporation	200ul	EUR 317.5

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30944-100ul	Biomatik Corporation	100ul	EUR 204.5

Nerve Growth Factor (NGF) Polyclonal Antibody
CAU30944-200ul	Biomatik Corporation	200ul	EUR 255.4

NGF rabbit polyclonal antibody, Biotin
PP1057B1	Origene Technologies GmbH	25 µg	Ask for price

NGF rabbit polyclonal antibody, Biotin
PP1057B2	Origene Technologies GmbH	50 µg	Ask for price

NGF rabbit polyclonal antibody, Purified
AP05352PU-N	Origene Technologies GmbH	1 mg	Ask for price

Morphometric evaluation additionally revealed the essential position of each neurotrophins in oligodendrocytes growth. These findings spotlight the significance of neurotrophic components in stimulating NSC differentiation and should pave a job for future research to develop neurotrophic issue alternative therapies to realize remyelination.