EXPRESS: Differentiation of the 50B11 dorsal root cells into NGF and GDNF responsive nociceptor subtypes
The embryonic rat dorsal root ganglion (DRG) neuron-derived 50B11 cell line is a promising sensory neuron mannequin expressing markers attribute of NGF and GDNF-dependent C-fibre nociceptors. Whether or not these cells have the capability to turn into distinct nociceptive subtypes primarily based on NGF- or GDNF-dependence has not been investigated.
Right here we present that by augmenting forskolin (FSK) and progress issue supplementation with NGF or GDNF, 50B11 cultures could be pushed to accumulate differential practical responses to frequent nociceptive agonists capsaicin and ATP respectively. As well as, to earlier research, we additionally show {that a} differentiated neuronal phenotype could be maintained for as much as 7 days.
Western blot evaluation of nociceptive marker proteins additional demonstrates that the 50B11 cells partially recapitulate the practical phenotypes of classical NGF-dependent (peptidergic) and GDNF-dependent (non-peptidergic) neuronal subtypes described in DRGs. Additional, 50B11 cells differentiated with NGF/FSK, however not GDNF/FSK, present sensitization to acute prostaglandin E2 therapy.
Lastly, RNA-Seq evaluation confirms that differentiation with NGF/FSK or GDNF/FSK produces two 50B11 cell subtypes with distinct transcriptome expression profiles. Gene ontology comparability of the 2 subtypes of differentiated 50B11 cells to rodent DRG neurons research exhibits vital overlap in matching or partially matching classes.
This transcriptomic evaluation will help future suitability evaluation of the 50B11 cells as a high-throughput nociceptor mannequin for a broad vary of experimental purposes. In conclusion, this examine exhibits that the 50B11 cell line is able to partially recapitulating options of two distinct forms of embryonic NGF and GDNF-dependent nociceptor-like cells.
A human related combination of persistent natural pollution (POPs) and perfluorooctane sulfonic acid (PFOS) improve nerve progress issue (NGF)-induced neurite outgrowth in PC12 cells
Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent natural pollution (POPs) are potential developmental neurotoxicants. We investigated their impact on neurite outgrowth in PC12 rat pheochromocytoma cells, in absence or presence of nerve progress issue (NGF), an inducer of neuronal differentiation. Cells had been uncovered for 72 h to an outlined combination of POPs with chemical composition and concentrations primarily based on blood ranges within the Scandinavian inhabitants.
We additionally evaluated perfluorooctane sulfonic acid (PFOS) alone, probably the most ample compound within the POP combination. Solely excessive concentrations of POP combination lowered tetrazolium salt (MTT) conversion. Excessive-content evaluation confirmed a lower in cell quantity, however no modifications for nuclear and mitochondrial mobile well being parameters.
Sturdy glutathione ranges had been noticed in NGF-differentiated cells. Stay imaging, utilizing the IncuCyte ZOOM platform indicated ongoing cell proliferation over time, however slower in presence of NGF. The pollution didn’t inhibit neuritogenesis, however somewhat elevated NGF-induced neurite size. PFOS induced neurite outgrowth to about 50% of the extent seen with the POP combination. Neither the POP combination nor PFOS affected neurite size within the absence of NGF. Our observations point out that lifelike advanced mixtures of environmental pollution can have an effect on neuronal connectivity by way of NGF-induced neurite outgrowth.
The biased ligands NGF and NT-Three differentially stabilize Trk-A dimers
Trk-A is a receptor tyrosine kinase (RTK) which performs an important position within the growth and functioning of the nervous system. Trk-A is expressed in neurons and alerts in response to 2 ligands, NGF and NT-3, with very totally different practical penalties. Thus, NGF and NT-Three are “biased” ligands for Trk-A. Because it has been hypothesized that biased RTK ligands induce differential stabilization of RTK dimers, right here we search to check this speculation for NGF and NT-3.
Particularly, we use Förster Resonance Power Switch (FRET) and Fluorescence Depth Fluctuation (FIF) spectroscopy to evaluate the energy of Trk-A interactions and Trk-A oligomer measurement within the presence of the 2 ligands. Whereas the distinction in Trk-A conduct in response to the 2 ligands has been beforehand attributed to variations of their binding to Trk-A within the endosomes at low pH, right here we additional present variations within the stabilities of the NGF and NT-Three certain Trk-A dimers within the plasma membrane and at impartial pH. We talk about the organic significance of those new findings and their implications for the design of Trk-A ligands with novel functionalities.
Results of NGF and BDNF on chondrocytes: a microarray evaluation
Osteoarthritis (OA) represents an inflammation-driven harm of articular tissues, progressively resulting in structural and practical joint impairment. The principle symptom of OA is ache. Though it has been nicely established that OA represents a complete joint illness, the supply of ache stays to be clarified. These days, it has been nicely established that neurotrophines expression is obvious in joints affected by OA. As well as, elevated NGF ranges are discovered within the synovial fluid of sufferers with inflammatory or degenerative rheumatic ailments, together with OA, rheumatoid arthritis and spondylarthritis.

Rising evidences point out that blocking NGF signaling utilizing an anti NGF agent (i.e. tanezumab) offers efficient ache aid. This examine analyzed the consequences of NGF and BDNF on cultured human chondrocytes by evaluating and their results on chondrogenesis, chondrocyte differentiation and cartilage degeneration by a microarray evaluation. The entire transcriptome evaluation carried out on this examine highlighted how NGF and BDNF may be capable to induce a proinflammatory response in human chondrocytes. Furthermore, NGF and BDNF remedies appears to have the ability to induce the activation of a number of genes concerned within the OA pathogenesis as IL17AR, HLA-DRB1, GDF-15, NR1D1, MCF2L and TGF-Beta.
Potential position of NGF, BDNF and their receptors in Oligodendrocytes differentiation from neural stem cell – an in-vitro examine
Neural stem cells (NSCs) or neuronal progenitor cells (NPCs) are cells able to differentiating into oligodendrocytes, myelin-forming cells which have the potential of remyelination. Mind-derived neurotrophic issue (BDNF) and Nerve progress issue (NGF) are two neurotrophic components which were studied to stimulate NSC differentiation thus taking part in a job in MS (A number of Sclerosis) pathogenesis and a number of other different demyelinating issues. Whereas a number of research have demonstrated the proliferative and protecting capabilities of those neurotrophic components, their mobile and molecular features are nonetheless not nicely understood.
Thus within the current examine we concentrate on understanding the position of those neurotrophins (BDNF and NGF) in oligodendrogenesis from NSCs. Each neurotrophic components have proven to advertise NSC proliferation and NSC differentiation significantly into oligodendroglial lineage in a dose dependent trend. Additional, to determine the position of those neurotrophins in NSC differentiation, we’ve got employed pharmacological inhibitors for TrkA and TrkB receptors in NSCs.
Using these inhibitors suppressed NSC differentiation into oligodendrocytes together with the down-regulation of phosphorylated ERK suggesting energetic involvement of ERK in functioning of those neurotrophins.
NGF Polyclonal Antibody |
ABP53296-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of NGF from Human. This NGF antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGF |
NGF Polyclonal Antibody |
41931-100ul |
SAB |
100ul |
EUR 302.4 |
NGF Polyclonal Antibody |
41931-50ul |
SAB |
50ul |
EUR 224.4 |
NGF Polyclonal Antibody |
41239-100ul |
SAB |
100ul |
EUR 302.4 |
NGF Polyclonal Antibody |
41239-50ul |
SAB |
50ul |
EUR 224.4 |
NGF Polyclonal Antibody |
ES4295-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against NGF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
NGF Polyclonal Antibody |
ES4295-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against NGF from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
NGF Polyclonal Antibody |
ES2958-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against NGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
NGF Polyclonal Antibody |
ES2958-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against NGF from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Ngf Polyclonal Antibody, HRP Conjugated |
A52043 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
NGF Polyclonal Antibody, HRP Conjugated |
A64863 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
Ngf Polyclonal Antibody, FITC Conjugated |
A52044 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
NGF Polyclonal Antibody, FITC Conjugated |
A64864 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
Ngf Polyclonal Antibody, Biotin Conjugated |
A52045 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
NGF Polyclonal Antibody, Biotin Conjugated |
A64865 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
|
|
Nerve Growth Factor (NGF) Polyclonal Antibody (Human) |
4-PAA105Hu01 |
Cloud-Clone |
-
EUR 260.40
-
EUR 2457.60
-
EUR 624.00
-
EUR 321.60
-
EUR 241.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF) |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human) |
4-PAA105Hu06 |
Cloud-Clone |
-
EUR 274.80
-
EUR 2678.40
-
EUR 674.40
-
EUR 340.80
-
EUR 247.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF) |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), PE |
4-PAA105Hu01-PE |
Cloud-Clone |
-
EUR 313.20
-
EUR 2563.20
-
EUR 748.80
-
EUR 385.20
-
EUR 216.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with PE. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), PE |
4-PAA105Hu06-PE |
Cloud-Clone |
-
EUR 330.00
-
EUR 2804.40
-
EUR 808.80
-
EUR 409.20
-
EUR 223.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with PE. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), APC |
4-PAA105Hu01-APC |
Cloud-Clone |
-
EUR 361.20
-
EUR 3174.00
-
EUR 906.00
-
EUR 452.40
-
EUR 240.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with APC. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), Cy3 |
4-PAA105Hu01-Cy3 |
Cloud-Clone |
-
EUR 432.00
-
EUR 4182.00
-
EUR 1158.00
-
EUR 553.20
-
EUR 270.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with Cy3. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), HRP |
4-PAA105Hu01-HRP |
Cloud-Clone |
-
EUR 332.40
-
EUR 2770.80
-
EUR 805.20
-
EUR 411.60
-
EUR 228.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with HRP. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), APC |
4-PAA105Hu06-APC |
Cloud-Clone |
-
EUR 382.80
-
EUR 3476.40
-
EUR 981.60
-
EUR 482.40
-
EUR 248.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with APC. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), Cy3 |
4-PAA105Hu06-Cy3 |
Cloud-Clone |
-
EUR 460.80
-
EUR 4585.20
-
EUR 1258.80
-
EUR 592.80
-
EUR 282.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with Cy3. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), HRP |
4-PAA105Hu06-HRP |
Cloud-Clone |
-
EUR 351.60
-
EUR 3032.40
-
EUR 870.00
-
EUR 438.00
-
EUR 235.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with HRP. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), FITC |
4-PAA105Hu01-FITC |
Cloud-Clone |
-
EUR 313.20
-
EUR 2563.20
-
EUR 748.80
-
EUR 385.20
-
EUR 216.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with FITC. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), FITC |
4-PAA105Hu06-FITC |
Cloud-Clone |
-
EUR 330.00
-
EUR 2804.40
-
EUR 808.80
-
EUR 409.20
-
EUR 223.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with FITC. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), Biotinylated |
4-PAA105Hu01-Biotin |
Cloud-Clone |
-
EUR 334.80
-
EUR 2397.60
-
EUR 734.40
-
EUR 400.80
-
EUR 246.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with Biotin. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), Biotinylated |
4-PAA105Hu06-Biotin |
Cloud-Clone |
-
EUR 350.40
-
EUR 2618.40
-
EUR 789.60
-
EUR 423.60
-
EUR 252.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with Biotin. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), APC-Cy7 |
4-PAA105Hu01-APC-Cy7 |
Cloud-Clone |
-
EUR 578.40
-
EUR 6204.00
-
EUR 1668.00
-
EUR 760.80
-
EUR 337.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with APC-Cy7. |
Nerve Growth Factor (NGF) Polyclonal Antibody (Human), APC-Cy7 |
4-PAA105Hu06-APC-Cy7 |
Cloud-Clone |
-
EUR 621.60
-
EUR 6808.80
-
EUR 1819.20
-
EUR 820.80
-
EUR 354.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Human Nerve Growth Factor (NGF). This antibody is labeled with APC-Cy7. |
Genorise® Biotinylated Rabbit NGF-B Polyclonal Antibody |
GR191051 |
Genorise Scientific |
100 µg |
EUR 398 |
Genorise® Biotinylated Feline NGF-B Polyclonal Antibody |
GR196018 |
Genorise Scientific |
100 µg |
EUR 398 |
Genorise® Biotinylated Monkey NGF-B Polyclonal Antibody |
GR197046 |
Genorise Scientific |
100 µg |
EUR 398 |
Genorise® Biotinylated Hamster NGF-B Polyclonal Antibody |
GR209018 |
Genorise Scientific |
100 µg |
EUR 398 |
NGFR p75 Polyclonal Antibody |
ABP51960-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 |
NGFR p75 Polyclonal Antibody |
ABP51960-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 |
NGFR p75 Polyclonal Antibody |
ABP51960-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 |
NGFR p75 Polyclonal Antibody |
ABP51961-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 at AA range: 90-170 |
NGFR p75 Polyclonal Antibody |
ABP51961-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 at AA range: 90-170 |
NGFR p75 Polyclonal Antibody |
ABP51961-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of NGFR p75 from Human, Mouse, Rat. This NGFR p75 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human NGFR p75 at AA range: 90-170 |
NGFR p75 Polyclonal Antibody |
41240-100ul |
SAB |
100ul |
EUR 302.4 |
NGFR p75 Polyclonal Antibody |
41240-50ul |
SAB |
50ul |
EUR 224.4 |
NGFR p75 Polyclonal Antibody |
ES2959-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against NGFR p75 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NGFR p75 Polyclonal Antibody |
ES2959-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against NGFR p75 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NGFR p75 Polyclonal Antibody |
ES2960-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against NGFR p75 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA |
NGFR p75 Polyclonal Antibody |
ES2960-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against NGFR p75 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA |
Polyclonal NGFB Antibody |
APR05620G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFB . This antibody is tested and proven to work in the following applications: |
Polyclonal NGFR Antibody |
AMM06682G |
Leading Biology |
0.1 mg |
EUR 790.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFR . This antibody is tested and proven to work in the following applications: |
Polyclonal NGFR / CD271 Antibody |
AMM06680G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFR / CD271 . This antibody is tested and proven to work in the following applications: |
Polyclonal NGFB Antibody (Center) |
APR06010G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFB (Center). This antibody is tested and proven to work in the following applications: |
Polyclonal NGFR Antibody (C-term) |
AMM06684G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFR (C-term). This antibody is tested and proven to work in the following applications: |
Polyclonal NGFR Antibody (C-term) |
AMM06685G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFR (C-term). This antibody is tested and proven to work in the following applications: |
Polyclonal NGFRAP1 / NADE / Bex Antibody |
APR02251G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NGFRAP1 / NADE / Bex . This antibody is tested and proven to work in the following applications: |
Polyclonal NGFRAP1 Antibody (C-Term) |
APG00487G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human NGFRAP1 (C-Term). This antibody is tested and proven to work in the following applications: |
Polyclonal AntibodyP1 Polyclonal Antibody |
ES11752-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Polyclonal AntibodyP1 Polyclonal Antibody |
ES11752-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against P1. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Polyclonal AntibodyP3 Polyclonal Antibody |
ES6454-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Polyclonal AntibodyP3 Polyclonal Antibody |
ES6454-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against P3 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Polyclonal AntibodyP5 Polyclonal Antibody |
ES4829-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Polyclonal AntibodyP5 Polyclonal Antibody |
ES4829-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against P5 from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Polyclonal AntibodyP2 Polyclonal Antibody |
ES10016-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Polyclonal AntibodyP2 Polyclonal Antibody |
ES10016-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against P2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Polyclonal AntibodyP4 Polyclonal Antibody |
ES10017-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Polyclonal AntibodyP4 Polyclonal Antibody |
ES10017-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against P4 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NGFR p75 Polyclonal Conjugated Antibody |
C41240 |
SAB |
100ul |
EUR 476.4 |
Polyclonal YY1 polyclonal antibody |
APR14018G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human YY1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal PML polyclonal antibody |
AMR09397G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PML polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal ETO polyclonal antibody |
APR00372G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ETO polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal SHH Polyclonal Antibody |
APR00434G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SHH Polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal ETO polyclonal antibody |
APR00435G |
Leading Biology |
0.1ml |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ETO polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal p53 polyclonal antibody |
APR00443G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human p53 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal G9a polyclonal antibody |
APR00448G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human G9a polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal SOX4 polyclonal antibody |
APR13475G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SOX4 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Rtf1 polyclonal antibody |
APR11187G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rtf1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Rtf1 polyclonal antibody |
APR11188G |
Leading Biology |
0.1ml |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rtf1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal RARA polyclonal antibody |
APR00370G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RARA polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal EzH2 polyclonal antibody |
APR00373G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EzH2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal BRD2 polyclonal antibody |
APR00374G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal BMI1 polyclonal antibody |
APR00376G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal EZH2 polyclonal antibody |
APR00436G |
Leading Biology |
0.1ml |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EZH2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal RARA polyclonal antibody |
APR00437G |
Leading Biology |
0.1ml |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RARA polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal EZH2 polyclonal antibody |
APR00439G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EZH2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal CHD4 polyclonal antibody |
APR00444G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CHD4 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal BRD2 polyclonal antibody |
APR00447G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BRD2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Hira polyclonal antibody |
APR00449G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Hira polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal SPI1 polyclonal antibody |
APR00451G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SPI1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal BMI1 polyclonal antibody |
APR00457G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BMI1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal CHD4 polyclonal antibody |
APR00459G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CHD4 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal PADI4 polyclonal antibody |
APR08916G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PADI4 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Med26 polyclonal antibody |
APR12517G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Med26 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Med26 polyclonal antibody |
APR12518G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Med26 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MeCP2 polyclonal antibody |
APR12525G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MeCP2 polyclonal antibody |
APR12526G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MeCP2 polyclonal antibody |
APR12527G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MeCP2 polyclonal antibody |
AMM06350G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MeCP2 polyclonal antibody |
AMM06351G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MeCP2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal PPARG polyclonal antibody |
AMR09459G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PPARG polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal PPARG polyclonal antibody |
AMR09486G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PPARG polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal MYH11 polyclonal antibody |
APR00438G |
Leading Biology |
0.1ml |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MYH11 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal CIITA polyclonal antibody |
APR00442G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human CIITA polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal HDAC1 polyclonal antibody |
APR00445G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HDAC1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Spt16 polyclonal antibody |
APR00446G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Spt16 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal BCL7C polyclonal antibody |
APR00452G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCL7C polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal LRWD1 polyclonal antibody |
APR00455G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LRWD1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal KDM4D polyclonal antibody |
APR00458G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human KDM4D polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Spt16 polyclonal antibody |
APR00460G |
Leading Biology |
0.05mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Spt16 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal JARID2 polyclonal antibody |
APR12450G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JARID2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal FKBP51 polyclonal antibody |
APR15992G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FKBP51 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal PIWIL2 polyclonal antibody |
APR17846G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PIWIL2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal ACTL6B polyclonal antibody |
AMM05547G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ACTL6B polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal JARID2 polyclonal antibody |
AMM06027G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JARID2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal ZMYND8 polyclonal antibody |
AMM08559G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ZMYND8 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal JMJD2c polyclonal antibody |
APR00375G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal JMJD2c polyclonal antibody |
APR00450G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human JMJD2c polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal LYDG10 polyclonal antibody |
APR00456G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LYDG10 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal AKR1B10 Polyclonal Antibody |
APG01659G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AKR1B10 Polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal FGF-1 Polyclonal Antibody |
APR00423G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FGF-1 Polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal p53K372me1 polyclonal antibody |
APR00440G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human p53K372me1 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal RFX-AP polyclonal antibody |
APR00441G |
Leading Biology |
0.05mg |
EUR 633.6 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RFX-AP polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal EIF2C1/2 polyclonal antibody |
APR00453G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human EIF2C1/2 polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal TGF-beta3 Polyclonal Antibody |
APG00008G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human TGF-beta3 Polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal sRANK Ligand Polyclonal Antibody |
APR00294G |
Leading Biology |
0.1mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human sRANK Ligand Polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Smc3K112/113ac polyclonal antibody |
APR00454G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Smc3K112/113ac polyclonal . This antibody is tested and proven to work in the following applications: |
Polyclonal Runx1/AML1-ETO polyclonal antibody |
APR00371G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Runx1/AML1-ETO polyclonal . This antibody is tested and proven to work in the following applications: |
L1 Polyclonal Antibody |
42503-100ul |
SAB |
100ul |
EUR 399.6 |
GH Polyclonal Antibody |
46804-100ul |
SAB |
100ul |
EUR 302.4 |
GH Polyclonal Antibody |
46804-50ul |
SAB |
50ul |
EUR 224.4 |
Ub Polyclonal Antibody |
46872-100ul |
SAB |
100ul |
EUR 302.4 |
Ub Polyclonal Antibody |
46872-50ul |
SAB |
50ul |
EUR 224.4 |
TF Polyclonal Antibody |
41603-50ul |
SAB |
50ul |
EUR 224.4 |
C6 Polyclonal Antibody |
27318-100ul |
SAB |
100ul |
EUR 302.4 |
C6 Polyclonal Antibody |
27318-50ul |
SAB |
50ul |
EUR 224.4 |
C2 Polyclonal Antibody |
27320-100ul |
SAB |
100ul |
EUR 302.4 |
C2 Polyclonal Antibody |
27320-50ul |
SAB |
50ul |
EUR 224.4 |
HR Polyclonal Antibody |
27586-100ul |
SAB |
100ul |
EUR 302.4 |
HR Polyclonal Antibody |
27586-50ul |
SAB |
50ul |
EUR 224.4 |
HR Polyclonal Antibody |
27636-100ul |
SAB |
100ul |
EUR 302.4 |
HR Polyclonal Antibody |
27636-50ul |
SAB |
50ul |
EUR 224.4 |
CS Polyclonal Antibody |
A52776 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
C5 Polyclonal Antibody |
A53695 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
MB Polyclonal Antibody |
A54065 |
EpiGentek |
100 µg |
EUR 684.66 |
MB Polyclonal Antibody |
A54256 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
gG Polyclonal Antibody |
A54852 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
NP Polyclonal Antibody |
A55006 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
E2 Polyclonal Antibody |
A55218 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
E7 Polyclonal Antibody |
A55263 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
C3 Polyclonal Antibody |
A55275 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
gD Polyclonal Antibody |
A55391 |
EpiGentek |
-
EUR 684.66
-
Ask for price
-
Ask for price
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
NP Polyclonal Antibody |
A55471 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
HP Polyclonal Antibody |
A55503 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
HA Polyclonal Antibody |
A55515 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
E6 Polyclonal Antibody |
A55631 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
gL Polyclonal Antibody |
A55914 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
|
- 100 µg
- 20 ul
- 50 ul
- 100 ul
|
Morphometric evaluation additionally revealed the essential position of each neurotrophins in oligodendrocytes growth. These findings spotlight the significance of neurotrophic components in stimulating NSC differentiation and should pave a job for future research to develop neurotrophic issue alternative therapies to realize remyelination.
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